公开(公告)号：US20050192331A1

公开(公告)日：2005-09-01

申请号：US11025373

申请日：2004-12-29

Applicant: David Zembower ,  David Eiznhamer

Inventor： David Zembower ,  David Eiznhamer

IPC: A61K31/4155 ,  C07D231/12 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  A61K31/416 ,  C07D43/02 ,  C07D45/02 ,  C07D49/02

CPC classification number: C07D231/12 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14

Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

Abstract translation: 本发明提供具有式（I）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述， 并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。

公开(公告)号：US20080015243A1

公开(公告)日：2008-01-17

申请号：US11891618

申请日：2007-08-13

Applicant: David Zembower ,  David Eiznhamer

Inventor： David Zembower ,  David Eiznhamer

IPC: A61K31/415 ,  A61P11/00 ,  C07D231/00 ,  C07D403/00

CPC classification number: C07D231/12 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14

Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

Abstract translation: 本发明提供具有式（I）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述， 并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。

公开(公告)号：US20050113369A1

公开(公告)日：2005-05-26

申请号：US11024615

申请日：2004-12-29

Applicant: David Zembower ,  David Eiznhamer

Inventor： David Zembower ,  David Eiznhamer

IPC: A61K31/4155 ,  C07D231/12 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  A61K31/541 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5377

CPC classification number: C07D231/12 ,  A61K31/4155 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14

Abstract: The present invention provides compounds having formula (1): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

Abstract translation: 本发明提供具有式（1）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述， 并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。

公开(公告)号：US20070232577A1

公开(公告)日：2007-10-04

申请号：US11728284

申请日：2007-03-23

Applicant: Ze-Qi Xu ,  Ali Koohang ,  Aye Aye Mar ,  Nathan Majewski ,  David Eiznhamer ,  Michael Flavin

Inventor： Ze-Qi Xu ,  Ali Koohang ,  Aye Aye Mar ,  Nathan Majewski ,  David Eiznhamer ,  Michael Flavin

IPC: A61K31/58 ,  A61K31/56 ,  C07J53/00

CPC classification number: C07J53/00

Abstract: The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.

Abstract translation: 本发明包括细胞增殖状态的特别是癌症和与癌症有关的病症的小分子抑制剂。 例如，相关的恶性肿瘤包括卵巢癌，子宫颈癌，乳腺癌，结肠直肠癌和成胶质细胞瘤等。 因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。 因此，本发明还包括包含该化合物的药物制剂和使用该化合物和制剂抑制癌症并治疗，预防或抑制前述疾病的方法。