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公开(公告)号：US20110104119A1
公开(公告)日：2011-05-05
申请号：US12983547
申请日：2011-01-03
申请人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
发明人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
CPC分类号： C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14144
摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。
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公开(公告)号：US20080269149A1
公开(公告)日：2008-10-30
申请号：US11793430
申请日：2005-12-15
申请人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
发明人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
CPC分类号： C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14144
摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。
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公开(公告)号：US09012224B2
公开(公告)日：2015-04-21
申请号：US12983547
申请日：2011-01-03
申请人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
发明人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
IPC分类号： C12N15/861 , C12N15/86
CPC分类号： C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14144
摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。
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公开(公告)号：US07892809B2
公开(公告)日：2011-02-22
申请号：US11793430
申请日：2005-12-15
申请人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
发明人： Dawn E. Bowles , Chengwen Li , Joseph E. Rabinowitz , Josh Grieger , Mavis Agbandje-McKenna , Richard Jude Samulski
IPC分类号： C12N7/01
CPC分类号： C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14144
摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.
摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。
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