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    Chimeric Vectors
    2.
    发明申请
    Chimeric Vectors 有权
    嵌合载体

    公开(公告)号：US20080269149A1

    公开(公告)日：2008-10-30

    申请号：US11793430

    申请日：2005-12-15

    申请人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    发明人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    IPC分类号： A61K31/7088 ,  C12N15/63 ,  A61P25/16 ,  A61P3/10 ,  A61P19/02 ,  A61P21/00 ,  A61P35/00

    CPC分类号： C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14144

    摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

    摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。

    POLYPEPTIDES AND VECTORS FOR TARGETING HER2/NEU EXPRESSING CELLS AND USES THEREOF
    3.
    发明申请
    POLYPEPTIDES AND VECTORS FOR TARGETING HER2/NEU EXPRESSING CELLS AND USES THEREOF 有权
    用于靶向HER2 / NEU表达细胞的多肽和载体及其用途

    公开(公告)号：US20140093533A1

    公开(公告)日：2014-04-03

    申请号：US14117871

    申请日：2012-05-18

    申请人： Kirsten Ariane Kelley Weigel-Van Aken ,  Mavis Agbandje-McKenna

    发明人： Kirsten Ariane Kelley Weigel-Van Aken ,  Mavis Agbandje-McKenna

    IPC分类号： C07K14/005 ,  C12N15/86

    CPC分类号： C07K14/005 ,  A61K9/5184 ,  A61K38/00 ,  A61K47/6929 ,  C07K16/32 ,  C07K2317/565 ,  C07K2319/735 ,  C07K2319/74 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2750/14322 ,  C12N2750/14343 ,  C12N2750/14345

    摘要： Various aspects of the invention provide for capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B19 capsid protein. Polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B19 capsid protein are also provided (e.g., SEQ ID NO: 2). Other aspects of the invention provide capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing a polypeptide comprising SEQ ID NO: 2. Also provided in various aspects of the invention are pharmaceutical compositions and methods of delivering therapeutic agents and/or reporter peptides/proteins to target cells. Finally, methods of treating diseases characterized by cells expression HER2/neu receptors are also provided.

    摘要翻译： 本发明的各个方面提供了包含多肽的衣壳，细小病毒衣壳，混合细小病毒衣壳，细小病毒载体，混合细小病毒载体，杂种细小病毒颗粒和细小病毒颗粒，其中序列YCDGFYACYMDV（SEQ ID NO：3）已被替代到VP2环中 的B19衣壳蛋白。 还提供了其中序列YCDGFYACYMDV（SEQ ID NO：3）已经被取代到B19衣壳蛋白的VP2环中的多肽（例如，SEQ ID NO：2）。 本发明的其它方面提供了包含SEQ ID NO：2的多肽的衣壳，细小病毒衣壳，混合细小病毒衣壳，细小病毒载体，混合细小病毒载体，杂交细小病毒颗粒和细小病毒颗粒。本发明的各个方面也提供药物组合物和 将治疗剂和/或报告肽/蛋白递送至靶细胞的方法。 最后，还提供了治疗以细胞表达HER2 / neu受体为特征的疾病的方法。

    Chimeric Vectors
    4.
    发明申请
    Chimeric Vectors 有权
    嵌合载体

    公开(公告)号：US20110104119A1

    公开(公告)日：2011-05-05

    申请号：US12983547

    申请日：2011-01-03

    申请人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    发明人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    IPC分类号： A61K35/76 ,  C12N5/00 ,  A61P21/00 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P27/02

    CPC分类号： C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14144

    摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

    摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。

    Chimeric vectors
    6.
    发明授权
    Chimeric vectors 有权
    嵌合载体

    公开(公告)号：US09012224B2

    公开(公告)日：2015-04-21

    申请号：US12983547

    申请日：2011-01-03

    申请人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    发明人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    IPC分类号： C12N15/861 ,  C12N15/86

    CPC分类号： C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14144

    摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

    摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。

    Chimeric vectors
    7.
    发明授权
    Chimeric vectors 有权
    嵌合载体

    公开(公告)号：US07892809B2

    公开(公告)日：2011-02-22

    申请号：US11793430

    申请日：2005-12-15

    申请人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    发明人： Dawn E. Bowles ,  Chengwen Li ,  Joseph E. Rabinowitz ,  Josh Grieger ,  Mavis Agbandje-McKenna ,  Richard Jude Samulski

    IPC分类号： C12N7/01

    CPC分类号： C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14144

    摘要： The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

    摘要翻译： 本发明部分地基于发现细小病毒（包括AAV）衣壳可以被工程化以包含来自其他细小病毒的小的选择性区域，其赋予期望的性质。 本发明人已经发现，在一些情况下，只要将单一氨基酸插入或从第一细小病毒（例如，AAV）置换到另一种细小病毒（例如AAV）的衣壳结构中以产生嵌合细小病毒就足够了 第一细小病毒对所得嵌合细小病毒的一个或多个所需性质和/或赋予第一细小病毒不表现的性质或者以较小程度存在的性质。