公开(公告)号：US20080171376A1

公开(公告)日：2008-07-17

申请号：US11929867

申请日：2007-10-30

Applicant: Dean M. SCHOLL ,  Steven R. WILLIAMS

Inventor： Dean M. SCHOLL ,  Steven R. WILLIAMS

IPC: C12N1/20 ,  C07H21/00 ,  C12N7/00 ,  C07K14/00

CPC classification number: C07K14/21 ,  C07K2319/35 ,  C07K2319/74

Abstract: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.

Abstract translation: 公开了天然存在的细菌素的修饰形式，例如绿脓假单胞菌的R型py霉素，作为在GRAS生物体中生产它们的方法。 细菌素在其尾纤维的末端被修饰，负责对其同源结合配偶体或受体（例如细菌表面上的那些）的结合特异性和亲和力。 还描述了在细菌表面上使用修饰的细菌素，例如结合受体（包括毒力或适应因子）的方法。