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公开(公告)号：US06274171B1
公开(公告)日：2001-08-14
申请号：US09488629
申请日：2000-01-20
IPC分类号： A61K952
CPC分类号： A61K31/137 , A61K9/1652 , A61K9/5047 , Y10S514/962
摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.
摘要翻译： 本发明涉及盐酸文拉法辛的24小时延长释放剂量制剂及其单位剂量形式，抗抑郁药与日常的片剂制剂相比可提供更好的对血浆水平的控制，其必须每天给予两次或更多次，并进一步提供较低的 恶心呕吐发生率高于传统药片。 更具体地说，本发明包括文拉法辛盐酸盐的延长释放制剂，其包含由盐酸文拉法辛，微晶纤维素和任选的用乙基纤维素和羟丙基甲基纤维素的混合物包被的羟丙基甲基纤维素组成的球形体中的治疗有效量的盐酸文拉法星。
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公开(公告)号：US06419958B2
公开(公告)日：2002-07-16
申请号：US09884412
申请日：2001-06-19
IPC分类号： A61K914
CPC分类号： A61K31/137 , A61K9/1652 , A61K9/5047 , Y10S514/962
摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.
摘要翻译： 本发明涉及盐酸文拉法辛的24小时延长释放剂量制剂及其单位剂量形式，抗抑郁药与日常的片剂制剂相比可提供更好的对血浆水平的控制，其必须每天给予两次或更多次，并进一步提供较低的 恶心呕吐发生率高于传统药片。 更具体地说，本发明包括文拉法辛盐酸盐的延长释放制剂，其包含由盐酸文拉法辛，微晶纤维素和任选的用乙基纤维素和羟丙基甲基纤维素的混合物包被的羟丙基甲基纤维素组成的球形体中的治疗有效量的盐酸文拉法星。
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公开(公告)号：US20080124392A1
公开(公告)日：2008-05-29
申请号：US12011367
申请日：2008-01-25
IPC分类号： A61K9/62
CPC分类号： A61K9/1652 , A61K9/5047
摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and further provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.
摘要翻译： 本发明涉及盐酸文拉法辛的24小时延长释放剂量制剂及其单位剂量形式，抗抑郁药与日常的片剂制剂相比可提供更好的对血浆水平的控制，其必须每天给予两次或更多次，并进一步提供较低的 恶心呕吐发生率高于传统药片。 更具体地说，本发明包括文拉法辛盐酸盐的延长释放制剂，其包含由盐酸文拉法辛，微晶纤维素和任选的用乙基纤维素和羟丙基甲基纤维素的混合物包被的羟丙基甲基纤维素组成的球形体中的治疗有效量的盐酸文拉法星。
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公开(公告)号：US06403120B1
公开(公告)日：2002-06-11
申请号：US09950965
申请日：2001-09-12
IPC分类号： A61K952
CPC分类号： A61K31/137 , A61K9/1652 , A61K9/5047 , Y10S514/962
摘要： This invention relates to a 24 hour extended release dosage formulation and unit dosage form thereof of venlafaxine hydrochloride, an antidepressant, which provides better control of blood plasma levels than conventional tablet formulations which must be administered two or more times a day and fiber provides a lower incidence of nausea and vomiting than the conventional tablets. More particularly, the invention comprises an extended release formulation of venlafaxine hydrochloride comprising a therapeutically effective amount of venlafaxine hydrochloride in spheroids comprised of venlafaxine hydrochloride, microcrystalline cellulose and, optionally, hydroxypropylmethylcellulose coated with a mixture of ethyl cellulose and hydroxypropylmethylcellulose.
摘要翻译： 本发明涉及盐酸文拉法辛的24小时延长释放剂量制剂及其单位剂型，抗抑郁药与日常的片剂制剂相比，可提供更好的对血浆水平的控制，每天必须给药2次或更多次，而纤维提供较低的 恶心呕吐发生率高于传统药片。 更具体地说，本发明包括文拉法辛盐酸盐的延长释放制剂，其包含由盐酸文拉法辛，微晶纤维素和任选的用乙基纤维素和羟丙基甲基纤维素的混合物包被的羟丙基甲基纤维素组成的球形体中的治疗有效量的盐酸文拉法星。
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公开(公告)号：US20110136772A1
公开(公告)日：2011-06-09
申请号：US13017770
申请日：2011-01-31
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/209 , A61K9/2826 , A61K9/2866 , A61K9/2886 , A61K31/565
摘要： Compositions particularly useful as coatings for solid dosage forms of therapeutic agents are provided, as are solid dosage forms comprising such coatings, processes for preparing such solid dosage forms, and the products of those processes. The coating compositions generally provide excellent strength and resistance to cracking, even when applied to flexible/swellable tablet cores such as hydrogel-type cores. The compositions also exhibit excellent odor-blocking characteristics.
摘要翻译： 提供特别可用作治疗剂的固体剂型涂层的组合物，包括这种包衣的固体剂型，制备这种固体剂型的方法以及这些方法的产物。 涂料组合物通常提供优异的强度和抗开裂性，即使当应用于柔性/可溶胀的片芯如水凝胶型芯时。 组合物还表现出优异的气味阻塞特性。
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公开(公告)号：US09845216B2
公开(公告)日：2017-12-19
申请号：US13498058
申请日：2010-09-24
申请人： Kevin B. Newhouse , Bruce E. Tait , John C. Clark
发明人： Kevin B. Newhouse , Bruce E. Tait , John C. Clark
IPC分类号： B65H27/00
CPC分类号： B65H27/00 , B65H2404/114 , B65H2701/1752
摘要： A method for conveying a web using an engagement cover (10) comprising resilient looped pile (16) engagement surface. Also, web conveying roller (12) having an engagement cover thereon.
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公开(公告)号：US07851387B2
公开(公告)日：2010-12-14
申请号：US12028589
申请日：2008-02-08
IPC分类号： B32B27/04
CPC分类号： C08F220/38 , Y10T428/3154 , Y10T442/2311 , Y10T442/232 , Y10T442/2754
摘要： A composition comprises a copolymer comprising repeating units derived from at least one co-reactant comprising two or more acrylate groups and repeating units derived from a fluoroacrylate comprising the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: C4F9—X—OH wherein: R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf═CnF2n+1, n=1 to 5, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoroacrylate monomer having 2 to about 30 carbon atoms in its alkylene portion; wherein the composition is coatable.
摘要翻译： 组合物包含共聚物，其包含衍生自至少一种包含两个或更多个丙烯酸酯基团的共反应物的重复单元和衍生自氟代丙烯酸酯的重复单元，所述重复单元包含以下反应产物：（a）至少一种由式C4F9- X-OH其中：R =氢或1至4个碳原子的烷基，m = 2至8，Rf = C n F 2n + 1，n = 1至5，y = 0至6，q = 1至8; （b）至少一种非支化对称二异氰酸酯; 和（c）至少一种羟基封端的（甲基）丙烯酸烷基酯或其亚烷基部分具有2-30个碳原子的2-氟丙烯酸酯单体; 其中所述组合物是可涂覆的。
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公开(公告)号：US07411020B2
公开(公告)日：2008-08-12
申请号：US11027606
申请日：2004-12-28
申请人： James G. Carlson , John C. Clark , James P. DiZio , David J. Kinning , Ramesh C. Kumar , Chetan P. Jariwala
发明人： James G. Carlson , John C. Clark , James P. DiZio , David J. Kinning , Ramesh C. Kumar , Chetan P. Jariwala
IPC分类号： C09D133/00 , B32B33/00
CPC分类号： C09D133/02 , Y10S525/902 , Y10T428/14
摘要： In one aspect, the invention provides a water-based release coating composition comprising a mixture of: A. from 0.1 to about 5 wt % of a fluoro(meth)acrylate (co)polymer or a fluorochemical urethane compound containing at least one fluorinated group having the formula —CF2)nCF3, wherein n is an integer from 1 to 3; B. from about 5 to about 99.9 wt % of a copolymer comprising the reaction product of a. from about 40 to about 70 wt % of an alkyl (meth)acrylate, wherein the alkyl group contains from 16 to 22 carbon atoms, b. from about 3 to about 20 wt % of (meth)acrylic acid, c. from about 20 to about 40 wt % acrylonitrile, and d. from 0 to about 15 wt % of vinyl monomer, other than acrylonitrile, wherein the sum of a. through d. equals 100%; and C. from 0 to about 94.9 wt % of an extender polymer, wherein the sum of A., B., and C. is 100% and wt % is based on the total amount of solids in the composition.
摘要翻译： 一方面，本发明提供了一种水性防粘涂料组合物，其包含以下混合物：A.从0.1至约5wt％的氟（甲基）丙烯酸酯（共）聚合物或含有至少一个氟化基团的含氟氨基甲酸酯化合物 具有式 - （CF 2）n CF 3，其中n为1至3的整数; B.约5至约99.9重量％的包含a的反应产物的共聚物。 约40至约70重量％的（甲基）丙烯酸烷基酯，其中烷基含有16至22个碳原子，b。 约3至约20重量％的（甲基）丙烯酸，c。 约20至约40重量％的丙烯腈，以及d。 0至约15重量％的乙烯基单体，除了丙烯腈，其中a。 通过d。 等于100％; 和C.0至约94.9重量％的增量聚合物，其中A.，B.和C.的总和为100％，wt％基于组合物中固体的总量。
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公开(公告)号：US07291688B2
公开(公告)日：2007-11-06
申请号：US11027605
申请日：2004-12-28
申请人： Zai-Ming Qiu , John C. Clark , Ramesh C. Kumar
发明人： Zai-Ming Qiu , John C. Clark , Ramesh C. Kumar
CPC分类号： C08F220/38
摘要： A copolymer comprises repeating units derived from at least one co-reactant comprising two or more mercapto functional groups, and repeating units derived from a fluoroacrylate comprising the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: C4F9—X—OH wherein: R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf=CnF2n+1, n=1 to 5, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoroacrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.
摘要翻译： 共聚物包含衍生自至少一种包含两个或多个巯基官能团的共反应物的重复单元和衍生自氟代丙烯酸酯的重复单元，该重复单元包含以下反应产物：（a）至少一种由下式表示的含氟醇： -line-formula description =“In-line Formulas”end =“lead”？> C 3 -X-OH <？in-line-formula description = “直链式”末端=“尾”→其中：R =氢或1至4个碳原子的烷基，m = 2至8，R f = C n n = 1〜5，y = 0〜6，q = 1〜8; （b）至少一种非支化的对称二异氰酸酯; 和（c）至少一种羟基封端的（甲基）丙烯酸烷基酯或其亚烷基部分具有2至约30个碳原子的2-氟丙烯酸酯单体。
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公开(公告)号：US07199197B2
公开(公告)日：2007-04-03
申请号：US11027604
申请日：2004-12-28
申请人： Gregg A. Caldwell , John C. Clark , David J. Kinning , Alan R. Kirk , Thomas P. Klun , Ramesh C. Kumar , Roger A. Mader , George G. I. Moore , Zai-Ming Qiu , Richard B. Ross
发明人： Gregg A. Caldwell , John C. Clark , David J. Kinning , Alan R. Kirk , Thomas P. Klun , Ramesh C. Kumar , Roger A. Mader , George G. I. Moore , Zai-Ming Qiu , Richard B. Ross
IPC分类号： C08F12/20
CPC分类号： C08F220/38 , C07C271/20 , C07C271/28 , C07C311/09 , Y10T442/2287
摘要： Fluoroacrylates comprise the reaction product of: (a) at least one fluorochemical alcohol represented by the formula: CnF2n+1—X—OH wherein: R=hydrogen or an alkyl group of 1 to 4 carbon atoms, m=2 to 8, Rf=CnF2n+1, y=0 to 6, and q=1 to 8; (b) at least one unbranched symmetric diisocyanate; and (c) at least one hydroxy-terminated alkyl (meth)acrylate or 2-fluoro acrylate monomer having 2 to about 30 carbon atoms in its alkylene portion.
摘要翻译： 氟丙烯酸酯包含反应产物
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