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公开(公告)号：US08986676B2
公开(公告)日：2015-03-24
申请号：US12093452
申请日：2006-11-10
CPC分类号： A61K38/1703
摘要： The present invention provides methods for inducing differentiation of an embryonic stem cell into a motor neuron using a motoneuronotrophic factor (MNTF) or its peptide analogs. The present invention further provides a method for isolating a population of stem cell derived motor neurons and a population of cells comprising the differentiated neural cells. Additionally, the present invention is directed to a method of enhancing the survival of the differentiated neural cells in long term cell cultures. Finally, the present invention provides compositions containing MNTF or its peptide analogs for therapeutic use in conjunction with stem cells.
摘要翻译： 本发明提供使用运动神经营养因子（MNTF）或其肽类似物诱导胚胎干细胞分化为运动神经元的方法。 本发明还提供了一种用于分离干细胞来源的运动神经元群和包含分化的神经细胞的细胞群的方法。 此外，本发明涉及增强长期细胞培养物中分化的神经细胞的存活的方法。 最后，本发明提供含有MNTF或其肽类似物的组合物，用于与干细胞联合治疗。
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公开(公告)号：US20090117085A1
公开(公告)日：2009-05-07
申请号：US12093452
申请日：2006-11-10
CPC分类号： A61K38/1703
摘要： The present invention provides methods for inducing differentiation of an embryonic stem cell into a motor neuron using a motoneuronotrophic factor (MNTF) or its peptide analogues. The present invention further provides a method for isolating a population of stem cell derived motor neurons and a population of cells comprising the differentiated neural cells. Additionally, the present invention is directed to a method of enhancing the survival of the differentiated neural cells in long term cell cultures. Finally, the present invention provides compositions containing MNTF or its peptide analogs for therapeutic use in conjunction with stem cells.
摘要翻译： 本发明提供使用运动神经营养因子（MNTF）或其肽类似物诱导胚胎干细胞分化为运动神经元的方法。 本发明还提供了一种用于分离干细胞来源的运动神经元群和包含分化的神经细胞的细胞群的方法。 此外，本发明涉及增强长期细胞培养物中分化的神经细胞的存活的方法。 最后，本发明提供含有MNTF或其肽类似物的组合物，用于与干细胞联合治疗。
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