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公开(公告)号：US20240271327A1
公开(公告)日：2024-08-15
申请号：US18643692
申请日：2024-04-23
Applicant: Denali Therapeutics Inc.
Inventor： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
CPC classification number: C07K16/2881 , C07K16/005 , C12N15/1058 , C40B20/00 , C40B30/04 , C40B50/00 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C12N2320/10
Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20240141058A1
公开(公告)日：2024-05-02
申请号：US18408477
申请日：2024-01-09
Applicant: Denali Therapeutics Inc.
Inventor： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
CPC classification number: C07K16/2881 , C07K16/005 , C12N15/1058 , C40B20/00 , C40B30/04 , C40B50/00 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C12N2320/10
Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20240024432A1
公开(公告)日：2024-01-25
申请号：US18464025
申请日：2023-09-08
Applicant: Denali Therapeutics Inc.
Inventor： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
CPC classification number: A61K38/40 , A61K47/644 , C07K16/2881 , C07K14/79 , C07K2317/52 , C07K2317/526 , C07K2317/94 , A61K38/00
Abstract: Provided herein are polypeptides that bind to a transferrin receptor, Fc dimers and fusion proteins comprising such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20220073609A1
公开(公告)日：2022-03-10
申请号：US17403406
申请日：2021-08-16
Applicant: Denali Therapeutics Inc.
Inventor： Mark S. Dennis , Sherie Duncan , Kathleen Lisaingo , Kathryn M. Monroe , Joshua I. Park , Rachel Prorok , Ju Shi , Ankita Srivastava , Bettina Van Lengerich , Riley Walsh
IPC: C07K16/28
Abstract: In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.
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公开(公告)号：US20210214438A1
公开(公告)日：2021-07-15
申请号：US17151006
申请日：2021-01-15
Applicant: Denali Therapeutics Inc.
Inventor： Mark S. Dennis , Zhenyu Gu , Mihalis S. Kariolis , Cathal S. Mahon , Kathryn M. Monroe , Joshua I. Park , Rachel Prorok , Adam P. Silverman , Bettina Van Lengerich
IPC: C07K16/28
Abstract: In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.
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Patent Agency Ranking
公开(公告)号：US20210130485A1
公开(公告)日：2021-05-06
申请号：US16921506
申请日：2020-07-06
Applicant: Denali Therapeutics Inc.
Inventor： Mark S. Dennis , Mihalis Kariolis , Wanda Kwan , Adam P. Silverman , Zachary K. Sweeney , Joy Yu Zuchero
IPC: C07K16/28
Abstract: The present disclosure relates generally to Fc polypeptide dimers that contain a non-native transferrin receptor (TfR) binding site, do not substantially deplete reticulocytes in vivo, but retain binding to the Fcγ receptor (FcγR). The present disclosure also relates to an Fc polypeptide dimer that contains a non-native site that specifically binds TfR on one of the Fc polypeptides; a modification or modifications on the Fc polypeptide containing the TfR-binding site that reduces FcγR binding when bound to TfR, where the other Fc polypeptide does not contain a TfR-binding site but retains FcγR binding.
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公开(公告)号：US20180235195A1
公开(公告)日：2018-08-23
申请号：US15923928
申请日：2018-03-16
Applicant: Denali Therapeutics Inc.
Inventor： Mark S. Dennis , Adam P. Silverman , Joy Yu Zuchero
IPC: A01K67/027 , C07K14/705 , G01N33/53
CPC classification number: A01K67/0278 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/705 , C07K14/70582 , C07K2319/00 , G01N33/5088 , G01N33/5308 , G01N2500/10
Abstract: In some aspects, the present invention provides chimeric transferrin receptor (TfR) polynucleotides and polypeptides. In other aspects, this invention provides chimeric TfR transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier.
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公开(公告)号：US12162948B2
公开(公告)日：2024-12-10
申请号：US18643692
申请日：2024-04-23
Applicant: Denali Therapeutics Inc.
Inventor： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20240018253A1
公开(公告)日：2024-01-18
申请号：US18465078
申请日：2023-09-11
Applicant: Denali Therapeutics Inc.
Inventor： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
IPC: C07K16/28
CPC classification number: C07K16/2881 , C07K2317/524
Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US11612150B2
公开(公告)日：2023-03-28
申请号：US16165324
申请日：2018-10-19
Applicant: Denali Therapeutics Inc.
Inventor： Mark S. Dennis , Adam P. Silverman , Joy Yu Zuchero
IPC: A01K67/027 , C07K14/705 , G01N33/53 , G01N33/50 , C07K14/79 , G01N33/68
Abstract: In some aspects, the present invention provides chimeric transferrin receptor (TfR) polynucleotides and polypeptides. In other aspects, this invention provides chimeric TfR transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier.
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