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公开(公告)号：US20090137524A1
公开(公告)日：2009-05-28
申请号：US12364879
申请日：2009-02-03
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A01N43/16 , C07D403/04 , A01N43/40 , A01P1/00 , A01N43/56 , C07D231/14
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。
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公开(公告)号：US20110196011A1
公开(公告)日：2011-08-11
申请号：US13089423
申请日：2011-04-19
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/415 , C07D231/38 , A61P33/00 , A01N43/56 , A01P7/00
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。
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公开(公告)号：US08084486B2
公开(公告)日：2011-12-27
申请号：US13089423
申请日：2011-04-19
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。
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公开(公告)号：US07960426B2
公开(公告)日：2011-06-14
申请号：US12364879
申请日：2009-02-03
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
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公开(公告)号：US07902232B2
公开(公告)日：2011-03-08
申请号：US11917389
申请日：2006-06-06
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/4439 , A61P33/00 , C07D231/10
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含一系列1-芳基-4-环丙基吡唑的组合产品，其中至少一个氟连接到环丙基环上，另外还有一种还有更多的治疗剂，特别是抗寄生虫剂。
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公开(公告)号：US07514464B2
公开(公告)日：2009-04-07
申请号：US11153103
申请日：2005-06-15
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/4439 , C07D231/10
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。
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公开(公告)号：US07435753B2
公开(公告)日：2008-10-14
申请号：US11013176
申请日：2004-12-15
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A61K31/4439 , C07D231/10
CPC分类号： A01N43/56 , A61K31/415 , A61K31/416 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D413/04
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中存在至少一个与环丙基环连接的氟的1-芳基-4-环丙基吡唑的范围，包含这些化合物的组合物，其合成方法及其作为杀寄生物的用途。
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公开(公告)号：US20090312371A1
公开(公告)日：2009-12-17
申请号：US11917389
申请日：2006-06-06
申请人： Denis Billen , Nathan Anthony Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Walshe
发明人： Denis Billen , Nathan Anthony Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Walshe
IPC分类号： A61K31/4439 , A61K31/415 , A61P33/00
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含一系列1-芳基-4-环丙基吡唑的组合产品，其中至少一个氟连接到环丙基环上，另外还有一种还有更多的治疗剂，特别是抗寄生虫剂。
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公开(公告)号：US20140017239A1
公开(公告)日：2014-01-16
申请号：US13904432
申请日：2013-05-29
申请人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号： A61K47/48 , A61K39/395
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号：US20120294848A1
公开(公告)日：2012-11-22
申请号：US13564103
申请日：2012-08-01
申请人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人： Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号： C07K17/00 , A61K39/395 , A61P37/02 , C07K16/00
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译： 本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在药物中的用途。
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