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    Guanidine derivatives as inhibitors of cell adhesion
    9.
    发明授权
    Guanidine derivatives as inhibitors of cell adhesion 有权
    胍衍生物作为细胞粘附抑制剂

    公开(公告)号：US06340679B1

    公开(公告)日：2002-01-22

    申请号：US09502577

    申请日：2000-02-11

    申请人： Anuschirwan Peyman ,  Jochen Knolle ,  Karl-Heinz Scheunemann ,  David William Will ,  Denis Carniato ,  Jean-Francois Gourvest ,  Thomas R. Gadek ,  Sarah Catherine Bodary

    发明人： Anuschirwan Peyman ,  Jochen Knolle ,  Karl-Heinz Scheunemann ,  David William Will ,  Denis Carniato ,  Jean-Francois Gourvest ,  Thomas R. Gadek ,  Sarah Catherine Bodary

    IPC分类号： C07D23916

    CPC分类号： C07D409/12 ,  C07D239/16

    摘要： The present invention relates to acylguanidine derivatives of the formula I in which R1, R2, R4, Ar, X and n have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the formula I are valuable pharmacologically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion. They inhibit, for example, bone resorption by osteoclasts and are suitable for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example osteoporosis. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceutical preparations, and pharmaceutical preparations comprising them.

    摘要翻译： 本发明涉及式Iin的酰基胍衍生物，其中R 1，R 2，R 4，Ar，X和n具有权利要求中所示的含义，其生理上可耐受的盐及其前药。 式I的化合物是有价值的药理活性化合物。 它们是玻连蛋白受体拮抗剂和细胞粘附抑制剂。 它们抑制例如破骨细胞的骨吸收，并且适用于治疗和预防至少部分由不期望的骨吸收程度引起的疾病，例如骨质疏松症。 本发明还涉及制备式I化合物的方法，其用途，特别是作为药物制剂中的活性成分，以及包含它们的药物制剂。