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1.发明授权Acylquanidine derivatives, method for preparing same, application as medicines and pharmaceutical compositions containing them 有权酰基胍衍生物，其制备方法，作为药物的应用和含有它们的药物组合物公开(公告)号：US06602878B1
公开(公告)日：2003-08-05
申请号：US09856351
申请日：2001-06-27
申请人： Denis Carniato , Thomas R. Gadek , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Jean-Marie Ruxer , Sarah C. Bodary
发明人： Denis Carniato , Thomas R. Gadek , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Jean-Marie Ruxer , Sarah C. Bodary
IPC分类号： C07D23916
CPC分类号： C07D239/16 , C07C279/22 , C07C311/06
摘要： Acylquanidines of the formula wherein the substituents are defined as in the specification which are antagonists of the vitronectin receptor and inhibitors of cell adhesion and bone resorption mediated by the osteoclasts.
摘要翻译： 在说明书中定义了取代基的甲酰基喹啉，其是玻连蛋白受体的拮抗剂和由破骨细胞介导的细胞粘附和骨吸收的抑制剂。
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公开(公告)号：US06391904B1
公开(公告)日：2002-05-21
申请号：US09856693
申请日：2001-06-29
申请人： Denis Carniato , Jean-Francois Gourvest , Jean-Marie Ruxer , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
发明人： Denis Carniato , Jean-Francois Gourvest , Jean-Marie Ruxer , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
IPC分类号： A61K314168
CPC分类号： C07C281/18 , C07D233/52
摘要： A compound of the formula where the substituents are defined in the specification and its pharmaceutically acceptable salts and prodrugs thereof useful as antagonists of vitronectin receptors.
摘要翻译： 在说明书中定义取代基的化合物及其药学上可接受的盐和前药，其可用作玻连蛋白受体的拮抗剂。
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3.发明授权Benzofurane derivatives, their preparation process, their use as medicaments and the pharmaceutical compositions containing them 失效苯并呋喃衍生物，其制备方法，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US06586442B2
公开(公告)日：2003-07-01
申请号：US10180253
申请日：2002-06-26
申请人： Denis Carniato , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
发明人： Denis Carniato , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
IPC分类号： A61K31505
CPC分类号： C07D405/12
摘要： A compound of the formula wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and it prodrug useful for treating osteoporosis.
摘要翻译： 取代基中的取代基的化合物如说明书及其药学上可接受的盐所定义，并且其用于治疗骨质疏松症的前药。
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4.发明授权Substituted 11.beta steroid derivatives, method for preparing same and intermediates of said method, use as medicine and compositions containing them 有权取代的11.β类固醇衍生物，其制备方法和所述方法的中间体，用作药物和含有它们的组合物公开(公告)号：US06500815B1
公开(公告)日：2002-12-31
申请号：US09914025
申请日：2001-12-17
申请人： Denis Carniato , Thomas R. Gadek , Jochen Knolle , Jean-Francois Gourvest , Anurschirwan Peyman , Sarah C. Bodary
发明人： Denis Carniato , Thomas R. Gadek , Jochen Knolle , Jean-Francois Gourvest , Anurschirwan Peyman , Sarah C. Bodary
IPC分类号： A61K3156
CPC分类号： C07J41/0005
摘要： The invention concerns compounds of formula (I) wherein: X, Y, R1, R2, Z, G are as defined in the description, the methods for preparing them and the intermediates in said method, their use as medicine and the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的化合物，其中：X，Y，R 1，R 2，Z，G如说明书中所定义，其制备方法和所述方法中的中间体，其用作药物和含有 他们。
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5.发明授权Benzofurane derivatives, preparation method, use as medicines and pharmaceutical compositions containing same 有权苯并呋喃衍生物，制备方法，用作药物和含有它们的药物组合物公开(公告)号：US06458801B1
公开(公告)日：2002-10-01
申请号：US09856542
申请日：2001-06-29
申请人： Denis Carniato , Thomas R. Gadek , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary
发明人： Denis Carniato , Thomas R. Gadek , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary
IPC分类号： A61K31505
CPC分类号： C07D405/12
摘要： A compound of the formula wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and its prodrug useful for treating osteoporosis.
摘要翻译： 取代基中的取代基的化合物如说明书及其药学上可接受的盐及其用于治疗骨质疏松症的前药所定义。
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6.发明授权Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them 有权三环化合物，其制备方法和该方法的中间体，它们作为药物的用途和含有它们的药物组合物公开(公告)号：US06459001B1
公开(公告)日：2002-10-01
申请号：US09769018
申请日：2001-01-25
申请人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
发明人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
IPC分类号： C07C25182
CPC分类号： C07D239/18 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/71 , C07C49/747 , C07C49/755 , C07C281/12 , C07C281/18 , C07C337/08 , C07C2603/30 , C07D233/52 , C07C49/753
摘要： The subject of the invention is the products of formula (I): in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.
摘要翻译： 本发明的主题是式（I）的产物：其中R1，R2，R3，R4，R5和G如说明书中所定义，虚线代表任选的第二键，以及与 酸和碱和酯，它们的制备方法和该方法的中间体，它们作为药物的用途和含有它们的药物组合物。
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7.发明授权Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same 有权具有对整联蛋白特异性的活性的三环化合物，特别是α2β3整联蛋白，其制备方法，其中间体，所述化合物作为药物的使用，以及含有该化合物的药物组合物公开(公告)号：US06221907B1
公开(公告)日：2001-04-24
申请号：US09155063
申请日：1999-02-02
申请人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
发明人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
IPC分类号： A61K3115
CPC分类号： C07D239/18 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/71 , C07C49/747 , C07C49/755 , C07C281/12 , C07C281/18 , C07C331/04 , C07C331/10 , C07C331/12 , C07C331/14 , C07C337/08 , C07C2603/30 , C07D233/52 , Y02P20/55 , C07C49/753
摘要： The subject of the invention is the products of formula (I): in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.
摘要翻译： 本发明的主题是式（I）的产物：其中R1，R2，R3，R4，R5和G如说明书中所定义，虚线代表任选的第二键，以及与 酸和碱和酯，它们的制备方法和该方法的中间体，它们作为药物的用途和含有它们的药物组合物。
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8.发明申请公开(公告)号：US20110142841A1
公开(公告)日：2011-06-16
申请号：US12589398
申请日：2009-10-22
申请人： Alexander Abbas , Sarah C. Bodary , Hilary Clark , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
发明人： Alexander Abbas , Sarah C. Bodary , Hilary Clark , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , C07K14/00 , C07K16/00 , G01N33/53 , A61K39/00 , A61P37/06
CPC分类号： C07K14/435 , A61K38/00
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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9.发明申请公开(公告)号：US20090181024A1
公开(公告)日：2009-07-16
申请号：US11537270
申请日：2006-09-29
申请人： Daryl T. Baldwin , Sarah C. Bodary , Andrew C. Chan , Hilary Clark , Janet K. Jackman , William I. Wood
发明人： Daryl T. Baldwin , Sarah C. Bodary , Andrew C. Chan , Hilary Clark , Janet K. Jackman , William I. Wood
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C07K14/00 , C07K19/00 , C07K16/18 , A61K38/16 , G01N33/536 , C12Q1/68 , C12Q1/02 , A61P37/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C12N2799/026 , C12Q1/6883 , C12Q2600/158 , G01N2500/10 , G01N2800/065 , G01N2800/205 , G01N2800/24
摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号：US06369204B1
公开(公告)日：2002-04-09
申请号：US09560743
申请日：2000-04-28
IPC分类号： C12P2108
CPC分类号： C07K16/2848 , A61K38/00 , Y10S530/867
摘要： The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.
摘要翻译： 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体，因此与骨吸收有关。 据信所公开的单克隆抗体识别出在α2β3上的独特表位，并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。
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