公开(公告)号：US07053175B1

公开(公告)日：2006-05-30

申请号：US09147362

申请日：1998-04-06

申请人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

发明人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

IPC分类号： A61K38/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16122

摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I) wherein Δ is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Ξ1-Ser-Ξ2-, -Ξ1-Gln-Ξ2-, or -Ξ1-Asn-Ξ2-, wherein -Ξ1 represents a peptide sequence of 0 to 9 amino acids and -Ξ2 represents a peptide sequence of 0 to 5 amino acids, Θ is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.