公开(公告)号：US20060234213A1

公开(公告)日：2006-10-19

申请号：US11402876

申请日：2006-04-13

申请人： Denis Marie Bernard Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  Francois Rieunier

发明人： Denis Marie Bernard Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  Francois Rieunier

IPC分类号： C12Q1/70 ,  A61K38/16 ,  C07K16/14

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16122

摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I) wherein Δis a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -1-Ser-2-, -1-Gln-2-, or -1-Asn-2-, wherein -1 represents a peptide sequence of 0 to 9 amino acids and -2 represents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.

公开(公告)号：US07838001B2

公开(公告)日：2010-11-23

申请号：US11402876

申请日：2006-04-13

申请人： Denis Marie Bernard Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  Francois Yves Rieunier

发明人： Denis Marie Bernard Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  Francois Yves Rieunier

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16122

摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I) wherein Δ is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Ξ1-Ser-Ξ2-, -Ξ1-Gln-Ξ2-, or -Ξ1-Asn-Ξ2-, wherein -Ξ1 represents a peptide sequence of 0 to 9 amino acids and -Ξ2 represents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.

摘要翻译： 具有13至33个氨基酸，线性形式或以半胱氨酸二硫键桥联环化的形式的单体类型的合成肽具有通式（I）：＆Dgr; -Z-TrpGlyCys-Θ-CysTyrThrSer-和OHgr ; （I）其中＆Dgr; 是生物素基，生物胞素基，氢原子，乙酰基（CH 3 CO-）基，可含有一个或两个硫醇的脂族链，醛官能团或胺官能团，Z代表肽序列 - ＆amp; Xgr; 1-Ser-和Xgr; 2-， - ＆Xgr; 1-Gln-和Xgr; 2-或 - ＆Xgr; 1-Asn-和Xgr; 2-，其中 - ＆amp; Xgr 1表示0至9个氨基酸的肽序列， - ＆Xgr; 2表示0至5个氨基酸的肽序列，Θis-Arg Gly Arg Leu Ile-（SEQ ID NO：15），-Arg Gly Arg Leu Val-（SEQ ID NO：16），-Arg Gly Lys Leu Ile-（SEQ ID NO：17），-Arg Gly Lys Leu Val-（SEQ ID NO：18），-Lys Gly Arg Leu Ile-（SEQ ID NO：19）或-Lys Gly Arg Leu Val-（ SEQ ID NO：20），连接于丝氨酸-CO-基团的OHgr，是羟基（-OH）基团，氨基（-NH 2）基团，具有1至6个碳原子的烷氧基基团，肽序列 式Val-＆Sgr;-Ψ其中＆Sgr; 表示式（AA1）-Trp Asn-（AA2） - （AA3）的序列，其中（AA1）表示不同于赖氨酸的氨基酸，（AA2）表示氨基酸，（AA3）为丝氨酸或苏氨酸残基 和附着在游离AA3氨基酸的-CO残基上的Ψ是OH，NH2或具有1至6个碳原子的烷氧基，和式-Val-Ψ的肽序列，其中Ψ附着于 缬氨酸的-CO残基是OH，NH 2或具有1至6个碳原子的烷氧基。

公开(公告)号：US07053175B1

公开(公告)日：2006-05-30

申请号：US09147362

申请日：1998-04-06

申请人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

发明人： Denis Marie Bernárd Chenebaux ,  Jean-Francois Hubert Delagneau ,  Stephane Jean Xavier Gadelle ,  François Yves Rieunier

IPC分类号： A61K38/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16122

摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I) wherein Δ is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Ξ1-Ser-Ξ2-, -Ξ1-Gln-Ξ2-, or -Ξ1-Asn-Ξ2-, wherein -Ξ1 represents a peptide sequence of 0 to 9 amino acids and -Ξ2 represents a peptide sequence of 0 to 5 amino acids, Θ is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.