公开(公告)号：US20160375062A1

公开(公告)日：2016-12-29

申请号：US15238993

申请日：2016-08-17

申请人： DePuy Synthes Products, Inc.

发明人： David C. Colter ,  Agnieszka Seyda ,  Charito S. Buensuceso ,  Anna Gosiewska

IPC分类号： A61K35/22 ,  C12N5/071

CPC分类号： A61K35/22 ,  A61K35/12 ,  C12N5/0686 ,  C12N5/0687 ,  C12N2533/40

摘要： Isolated or purified mammalian kidney-derived cell populations from mammalian kidney tissue are provided. Methods are provided for the isolation and purification of the mammalian kidney-derived cell population. Methods for treating kidney disease are provided by administration of the isolated or purified mammalian kidney-derived cell population to a mammalian subject.

摘要翻译： 提供来自哺乳动物肾组织的分离或纯化的哺乳动物肾源细胞群。 提供了用于分离和纯化哺乳动物肾源细胞群体的方法。 通过向哺乳动物受试者施用分离或纯化的哺乳动物肾来源的细胞群来提供治疗肾脏疾病的方法。

公开(公告)号：US09579348B2

公开(公告)日：2017-02-28

申请号：US14252132

申请日：2014-04-14

申请人： Depuy Synthes Products, Inc.

发明人： Charito S. Buensuceso ,  David C. Colter ,  Brian C. Kramer ,  Agnieszka Seyda

IPC分类号： A61K35/22 ,  A61K9/00 ,  A61K9/16 ,  A61K9/48 ,  A61L27/34 ,  A61L27/36 ,  A61K35/12

CPC分类号： A61K35/22 ,  A61K9/0024 ,  A61K9/1652 ,  A61K9/48 ,  A61K35/12 ,  A61L27/34 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/3683

摘要： Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.

摘要翻译： 提供包含包封在聚合物珠内的肾组织的治疗性植入物。 还公开了用于治疗受试者的疾病状态的方法，包括在所述受试者内植入包含封装在聚合物珠内的肾组织的治疗性植入物。 还提供了用于制备治疗性植入物的方法，包括：提供肾组织; 将肾组织与包含聚合物的溶液混合，由此形成组织 - 聚合物悬浮液; 将组织 - 聚合物悬浮液挤出成珠形成溶液，由此形成治疗性植入物，其包含所述聚合物的珠粒，肾组织在其中被包封。

公开(公告)号：US10413571B2

公开(公告)日：2019-09-17

申请号：US15238993

申请日：2016-08-17

申请人： DePuy Synthes Products, Inc.

发明人： David C. Colter ,  Agnieszka Seyda ,  Charito S. Buensuceso ,  Anna Gosiewska

IPC分类号： C12N5/071 ,  A61K35/22 ,  A61K35/12

摘要： Isolated or purified mammalian kidney-derived cell populations from mammalian kidney tissue are provided. Methods are provided for the isolation and purification of the mammalian kidney-derived cell population. Methods for treating kidney disease are provided by administration of the isolated or purified mammalian kidney-derived cell population to a mammalian subject.