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公开(公告)号：US20050153972A1
公开(公告)日：2005-07-14
申请号：US11002022
申请日：2004-12-01
IPC分类号： C07D249/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K31/501 , A61K31/4192 , A61K31/4439 , C07D43/02
CPC分类号： C07D401/12 , C07D249/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar 1，X，R 3，R 4，R 5， 和R 6'在本文中定义。 本发明的化合物抑制细胞因子的产生，因此可用于治疗细胞因子介导的疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20070275946A1
公开(公告)日：2007-11-29
申请号：US11839136
申请日：2007-08-15
申请人： Ronald Aungst , Derek Cogan , Amy Davis , Daniel Goldberg , Ming-Hong Hao , Zhaoming Xiong
发明人： Ronald Aungst , Derek Cogan , Amy Davis , Daniel Goldberg , Ming-Hong Hao , Zhaoming Xiong
IPC分类号： A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20050245536A1
公开(公告)日：2005-11-03
申请号：US11119524
申请日：2005-04-29
申请人： Ming-Hong Hao , Zhaoming Xiong , Ronald Aungst , Amy Davis , Derek Cogan , Daniel Goldberg
发明人： Ming-Hong Hao , Zhaoming Xiong , Ronald Aungst , Amy Davis , Derek Cogan , Daniel Goldberg
IPC分类号： A61K31/496 , A61K31/506 , C07D401/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号： C07D401/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07511042B2
公开(公告)日：2009-03-31
申请号：US11002022
申请日：2004-12-01
申请人： Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
发明人： Derek Cogan , Daniel R. Goldberg , Abdelhakim Hammach , Matthew Russell Netherton , Ronald A. Aungst
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/12 , C07D249/06 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物，其中Ar1，X，R3，R4，R5和R6如本文所定义。 本发明的化合物抑制细胞因子的产生，因此可用于治疗细胞因子介导的疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20050256113A1
公开(公告)日：2005-11-17
申请号：US11120735
申请日：2005-05-03
申请人： Derek Cogan , Ming-Hong Hao , Alan Swinamer , Ronald Aungst
发明人： Derek Cogan , Ming-Hong Hao , Alan Swinamer , Ronald Aungst
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/4196 , A61K31/423 , A61K31/4439 , A61K31/58 , C07D231/14 , C07D233/90 , C07D401/12 , C07D413/02 , C07D43/02
CPC分类号： C07D233/90 , C07D231/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US20060079519A1
公开(公告)日：2006-04-13
申请号：US11074354
申请日：2005-03-07
申请人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
发明人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
IPC分类号： A61K31/538 , A61K31/53 , A61K31/506 , A61K31/497 , C07D43/02 , C07D413/02
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：US20060100204A1
公开(公告)日：2006-05-11
申请号：US11270207
申请日：2005-11-09
申请人： Derek Cogan , Matthew Netherton
发明人： Derek Cogan , Matthew Netherton
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/501 , C07D413/02 , C07D403/02
CPC分类号： C07D403/14 , C07D401/04 , C07D401/14 , C07D403/04
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：US20070142371A1
公开(公告)日：2007-06-21
申请号：US11668704
申请日：2007-01-30
申请人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
发明人： Derek Cogan , Ming-Hong Hao , Victor Kamhi , Matthew Netherton , Alan Swinamer , Craig Miller
IPC分类号： A61K31/538 , A61K31/53 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/433 , A61K31/423 , A61K31/4196 , A61K31/4192 , A61K31/4178 , C07D413/02 , C07D403/02
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开的抑制细胞因子产生的式（I）化合物，其涉及炎症过程，因此可用于治疗涉及炎症的疾病和病理状态，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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公开(公告)号：US09181272B2
公开(公告)日：2015-11-10
申请号：US14262828
申请日：2014-04-28
申请人： Michael Balestra , Jennifer Burke , Zhidong Chen , Derek Cogan , Lee Fader , Xin Guo , Bryan McKibben , Daniel Richard Marshall , Peter Allen Nemoto , Hui Yu
发明人： Michael Balestra , Jennifer Burke , Zhidong Chen , Derek Cogan , Lee Fader , Xin Guo , Bryan McKibben , Daniel Richard Marshall , Peter Allen Nemoto , Hui Yu
IPC分类号： C07D471/02 , C07D498/04 , C07D471/04
CPC分类号： C07D498/04 , C07D471/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，W，Y，m和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US07485657B2
公开(公告)日：2009-02-03
申请号：US11120735
申请日：2005-05-03
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D233/90 , C07D231/14 , C07D401/12
摘要： Disclosed are compounds of formula (I) The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and the pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了式（I）的化合物该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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