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    METHODS RELATING TO IDENTIFICATION OF SUSCEPTIBILITY TO LIVER INJURY
    1.
    发明申请
    METHODS RELATING TO IDENTIFICATION OF SUSCEPTIBILITY TO LIVER INJURY 审中-公开
    关于识别伤害性不便的方法

    公开(公告)号：US20130183668A1

    公开(公告)日：2013-07-18

    申请号：US13667832

    申请日：2012-11-02

    申请人： Derek Mann ,  Jelena Mann ,  Mujdat Zeybal

    发明人： Derek Mann ,  Jelena Mann ,  Mujdat Zeybal

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/70567 ,  G01N2800/085 ,  G01N2800/56

    摘要： The present invention relates to methods for identifying susceptibility of impaired hepatic wound healing in a patient, most particularly by identifying modifications of the of PPAR-γ and TGFβ1 genes. It further relates to stratifying populations of patients to determine susceptibility to impaired hepatic wound healing and direct appropriate healthcare resources. More specifically methods can be used to stratify liver disease patient populations to identify those most likely to progress to cirrhosis, or to identify the likelihood that a patient with liver disease will progress to having cirrhosis.

    摘要翻译： 本发明涉及鉴别患者肝损伤愈合易感性的方法，特别是通过鉴定PPAR-γ和TGFbeta1基因的修饰。 它进一步涉及分层的患者群体，以确定肝损伤愈合受损的易感性和直接适当的保健资源。 更具体地，可以使用方法来分层肝病患者群体，以鉴定最可能进展为肝硬化的那些，或者确定肝病患者进展为肝硬化的可能性。

    METHODS RELATING TO IDENTIFICATION OF SUSCEPTIBILITY TO LIVER INJURY
    2.
    发明申请
    METHODS RELATING TO IDENTIFICATION OF SUSCEPTIBILITY TO LIVER INJURY 审中-公开
    关于识别伤害性不便的方法

    公开(公告)号：US20140357733A1

    公开(公告)日：2014-12-04

    申请号：US14448589

    申请日：2014-07-31

    申请人： Derek Mann ,  Jelena Mann ,  Mujdat Zeybal

    发明人： Derek Mann ,  Jelena Mann ,  Mujdat Zeybal

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/70567 ,  G01N2800/085 ,  G01N2800/56

    摘要： The present invention relates to methods for identifying susceptibility of impaired hepatic wound healing in a patient, most particularly by identifying modifications of the of PPAR-γ and TGFβ1 genes. It further relates to stratifying populations of patients to determine susceptibility to impaired hepatic wound healing and direct appropriate healthcare resources. More specifically methods can be used to stratify liver disease patient populations to identify those most likely to progress to cirrhosis, or to identify the likelihood that a patient with liver disease will progress to having cirrhosis.

    摘要翻译： 本发明涉及鉴别患者肝损伤愈合易感性的方法，特别是鉴定PPAR-γ和TGF-β1基因的修饰。 它进一步涉及分层的患者群体，以确定肝损伤愈合受损的易感性和直接适当的保健资源。 更具体地，可以使用方法来分层肝病患者群体，以鉴定最可能进展为肝硬化的那些，或者确定肝病患者进展为肝硬化的可能性。

    Chemical Compounds
    4.
    发明申请
    Chemical Compounds 审中-公开
    化学化合物

    公开(公告)号：US20080090788A1

    公开(公告)日：2008-04-17

    申请号：US11794711

    申请日：2006-01-05

    申请人： Graham Packham ,  Arasu Ganesan ,  Derek Mann ,  Fiona Natarajan ,  Srinvian Natarajan

    发明人： Graham Packham ,  Arasu Ganesan ,  Derek Mann ,  Fiona Natarajan ,  Srinvian Natarajan

    IPC分类号： A61K31/63 ,  A61K31/635 ,  A61K31/655 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  C07C311/38 ,  C09B29/00

    CPC分类号： A61K31/63 ,  A61K31/192

    摘要： Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as a Nuclear Factor-kB (NF-kB) inhibitor wherein: A has the following structure; Z is —COOH, —P(O)(OH)2 or —SO2OH; each R1 is the same or different and is halogen, hydroxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 alkylthio, thio, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano or —CO2R′, wherein R′ represents hydrogen or C1-6 alkyl; n is 0, 1, 2 or 3; R2 is hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; Y is a linking group; and X is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, -M-aryl, -M-heteroaryl, -M-carbocyclyl or -M-heterocyclyl, wherein M is C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene, -Q-Het-Q′- or -Q-Het- wherein Q and Q′ are the same or different and are C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene and Het is selected from —NR′—, —O—, —S—, —SO2—, —SO—, —C(O)—O—, —OC(O), —CO—, —C(O)—NR′— or —NR′—C(O)— wherein R′ is as defined above, provided that: when n is 0, Z is —COOH, R2 is hydrogen and Y is —N═N—, X is other than 2-pyridyl.

    摘要翻译： 式（I）化合物或其药学上可接受的盐在制备用作核因子kB（NF-kB）抑制剂的药物中的用途，其中：A具有以下结构; Z是-COOH，-P（O）（OH）2或-SO 2 OH; 每个R 1相同或不同，为卤素，羟基，C 1-6烷基，C 2-6链烯基，C 1-6个烷基; n为0,1,2或3; R 2是氢，C 1-6烷基，C 2-6链烯基或C 2-6-6炔基 ; Y是连接组; 且X为C 1-6烷基，C 2-6链烯基，C 2-6炔基，芳基，杂芳基，碳环基，杂环基， -M-芳基，-M-杂芳基，-M-碳环基或-M-杂环基，其中M为C 1-6亚烷基，C 2-6亚烯基，C C 2-6 - 亚炔基，-Q-Het-Q'或-Q-Het-，其中Q和Q'相同或不同，为C 1-6 - 亚烷基 C 2-6亚烯基或C 2-6亚炔基，Het选自-NR' - ， - O - ， - S - ， - SO 2 （O）-O-，-OC（O），-CO-， - C（O）-NR'或-NR'-C（O） - ，其中R 其定义如下：当n为0时，Z为-COOH，R 2为氢，Y为-NN-，X为2-吡啶基。

    Apparatus for the oral administration of capsules to animals
    5.
    发明授权
    Apparatus for the oral administration of capsules to animals 失效
    用于口服胶囊给动物的装置

    公开(公告)号：US4637816A

    公开(公告)日：1987-01-20

    申请号：US682001

    申请日：1984-12-12

    申请人： Derek Mann

    发明人： Derek Mann

    IPC分类号： A61D7/00 ,  A61M5/18

    CPC分类号： A61D7/00

    摘要： Apparatus for the oral administration of capsules to animals, particularly ruminants such as sheep, comprises a tubular member adapted to be inserted into the animal's mouth so that the tip of the tubular member is near the root of the animal's tongue, means for introducing a capsule into the tubular member and for propelling the capsule to its tip, in which the tip of the tubular member consists of two tip portions extending from the mouth of the tubular member and laterally spaced from one another so as to define a cavity in which a capsule is deposited at the root of the animal's tongue. The top of the tubular member has a convexly curved upper surface adapted to engage the animal's soft palate to encourage a swallowing reaction, and a lower surface shaped to engage and restrain movement of the dorsum and the front part of the animal's tongue. Apparatus is disclosed in which the means for propelling the capsule along the tubular member comprises means for supplying air or gas under pressure to the tubular member. The use of gas to propel the capsule ensures that it is adminstered rapidly with no risk of damage to the animal.

    摘要翻译： PCT No.PCT / GB84 / 00143 Sec。 371日期1984年12月12日 102（e）日期1984年12月12日PCT提交1984年4月26日PCT公布。 出版物WO84 / 04239 日本1984年11月8日。用于口服给予动物，特别是反刍动物如绵羊的胶囊的装置包括适于插入动物口中的管状构件，使得管状构件的尖端靠近动物的根部 舌头，用于将胶囊引入管状构件并用于将胶囊推进到其尖端的装置，其中管状构件的尖端由从管状构件的嘴部延伸并且彼此横向间隔开的两个尖端部分组成，以便 限定一个空腔，胶囊在其中沉积在动物舌头的根部。 管状构件的顶部具有凸起弯曲的上表面，其适于接合动物的软腭以促进吞咽反应，以及下表面，其形状为接合和限制动物舌头的背部和前部的运动。 公开了一种装置，其中用于沿着管状构件推进胶囊的装置包括用于在压力下向管状构件供应空气或气体的装置。 使用气体来推动胶囊确保其迅速管理，没有损害动物的风险。