摘要:
The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.
摘要:
Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of γ-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
摘要翻译:描述了取代的喹诺酮羧酸及其衍生物。 这些化合物以治疗相关的方式通过新的位点调节γ-氨基丁酸(GABA)的作用,并且可用于改善适于调节GABA受体复合物的CNS失调, SUB> A SUB>受体复合物。