公开(公告)号：US20230115784A1

公开(公告)日：2023-04-13

申请号：US18064676

申请日：2022-12-12

申请人： Dermala, Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/60 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/70 ,  A61K31/194 ,  A61K31/20 ,  A61K31/327 ,  A61K31/4402 ,  A61K33/30 ,  A61K35/745 ,  A61K35/747 ,  A61K36/752 ,  A61K36/886 ,  A61K45/06 ,  A61K47/44 ,  A61K47/10 ,  A61K8/36 ,  A61K8/362 ,  A61Q19/00

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of acne vulgaris. The compositions include succinic acid and an API selected from the group consisting of salicylic acid, azelaic acid, picolinic acid, benzoyl peroxide, antibiotic, retinoid and combinations thereof in a pharmaceutically acceptable preparation. The compositions that include the combination of succinic acid and another API produce improved efficacy in treating acne vulgaris.

公开(公告)号：US20220079902A1

公开(公告)日：2022-03-17

申请号：US17483759

申请日：2021-09-23

申请人： Dermala, Inc.

发明人： Lada RASOCHOVA ,  Edward T. KISAK ,  John NEWSAM

IPC分类号： A61K31/194 ,  A61P17/10

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of acne vulgaris. The compositions include succinic acid, Brij®-30 and a molecular penetration enhancer in a pharmaceutically acceptable preparation. The molecular penetration enhancer may include one or more of DMSO, dimethyl isosorbide, lauryl lactate and isopropyl myristate.

公开(公告)号：US20210353647A1

公开(公告)日：2021-11-18

申请号：US17327559

申请日：2021-05-21

申请人： Dermala, Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/60 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/70 ,  A61K31/194 ,  A61K31/20 ,  A61K31/327 ,  A61K31/4402 ,  A61K33/30 ,  A61K35/745 ,  A61K35/747 ,  A61K36/752 ,  A61K36/886 ,  A61K45/06 ,  A61K47/44 ,  A61K47/10 ,  A61K8/36 ,  A61K8/362 ,  A61Q19/00

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of acne vulgaris. The compositions include succinic acid and an API selected from the group consisting of salicylic acid, azelaic acid, picolinic acid, benzoyl peroxide, antibiotic, retinoid and combinations thereof in a pharmaceutically acceptable preparation. The compositions that include the combination of succinic acid and another API produce improved efficacy in treating acne vulgaris.

公开(公告)号：US20190290662A1

公开(公告)日：2019-09-26

申请号：US16302637

申请日：2017-05-18

申请人： Dermala Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/60 ,  A61K31/194 ,  A61K9/00 ,  A61P17/10 ,  A61K31/4402 ,  A61K31/20 ,  A61K31/327 ,  A61K36/886 ,  A61K36/752 ,  A61K9/70 ,  A61K9/06 ,  A61K35/747 ,  A61K35/745 ,  A61K33/30

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of acne vulgaris. The compositions include succinic acid and an API selected from the group consisting of salicylic acid, azelaic acid, picolinic acid, benzoyl peroxide, antibiotic, retinoid and combinations thereof in a pharmaceutically acceptable preparation. The compositions that include the combination of succinic acid and another API produce improved efficacy in treating acne vulgaris.

公开(公告)号：US20220273595A1

公开(公告)日：2022-09-01

申请号：US17746796

申请日：2022-05-17

申请人： Dermala, Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/19 ,  A61P17/00 ,  A61P31/04 ,  A61P29/00 ,  A61K9/00 ,  A61K9/06 ,  A61K31/197 ,  A61K31/22 ,  A61K31/225 ,  A61K31/25 ,  A61K31/436 ,  A61K31/56 ,  A61K36/899 ,  A61K39/395 ,  A61K47/46 ,  C07K16/28 ,  C07K16/42 ,  A61K31/194 ,  A61K31/58 ,  A61K31/573 ,  A61K31/221 ,  A61K45/06

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of eczema. The compositions may include propionic acid and/or non-steroidal esters of propionic acid. The compositions may further include a corticosteroid, immunomodulator, antibiotic, antibody, colloidal oatmeal, conditioned media prepared by bacterial fermentation, short chain fatty acids, picolinic acid, or emollient. The method of treatment may include analysis of the skin microbiome.

公开(公告)号：US20190290605A1

公开(公告)日：2019-09-26

申请号：US16302639

申请日：2017-05-18

申请人： Dermala Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/19 ,  A61K9/00 ,  A61K31/225 ,  A61K31/22 ,  A61K31/25 ,  A61K31/197 ,  A61K31/56 ,  A61K31/436 ,  A61K39/395 ,  C07K16/42 ,  C07K16/28 ,  A61K36/899 ,  A61K47/46 ,  A61P17/00 ,  A61P31/04 ,  A61K9/06 ,  A61P29/00

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of eczema. The compositions may include propionic acid and/or non-steroidal esters of propionic acid. The compositions may further include a corticosteroid, immunomodulator, antibiotic, antibody, colloidal oatmeal, conditioned media prepared by bacterial fermentation, short chain fatty acids, picolinic acid, or emollient. The method of treatment may include analysis of the skin microbiome.