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16 条记录 (耗时 0.035 秒)

    Piperazine derivative having affinity for the histamine H3 receptor
    5.
    发明授权
    Piperazine derivative having affinity for the histamine H3 receptor 失效
    对组胺H3受体具有亲和性的哌嗪衍生物

    公开(公告)号：US08288389B2

    公开(公告)日：2012-10-16

    申请号：US12676158

    申请日：2008-09-04

    申请人： Desmond John Best ,  Sing Yeung Mak ,  Barry Sidney Orlek ,  Geracimos Rassias ,  Pamela Joan Theobald

    发明人： Desmond John Best ,  Sing Yeung Mak ,  Barry Sidney Orlek ,  Geracimos Rassias ,  Pamela Joan Theobald

    IPC分类号： A61K31/496 ,  C07D309/12

    CPC分类号： C07D309/12

    摘要： The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human. The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

    摘要翻译： 本发明涉及1-（1-甲基乙基）-4 - {[4-（四氢-2H-吡喃-4-基氧基）苯基]羰基}哌嗪或其药学上可接受的盐，特别是其盐酸盐和结晶 形式的盐酸盐; 制备化合物或其盐的方法; 含有它的组合物; 以及其用于治疗或预防神经或精神疾病，例如认知障碍，疲劳或睡眠障碍，例如在哺乳动物如人中的用途。 该化合物或其盐对组胺H3受体具有亲和性，并且是拮抗剂和/或反向激动剂。

    Piperazine Derivative Having Affinity for the Histamine H3 Receptor
    8.
    发明申请
    Piperazine Derivative Having Affinity for the Histamine H3 Receptor 失效
    哌嗪衍生物具有组胺H3受体的亲和力

    公开(公告)号：US20100204242A1

    公开(公告)日：2010-08-12

    申请号：US12676158

    申请日：2008-09-04

    申请人： Desmond John Best ,  Sing Yeung Mak ,  Barry Sidney Orlek ,  Geracimos Rassias ,  Pamela Joan Theobald

    发明人： Desmond John Best ,  Sing Yeung Mak ,  Barry Sidney Orlek ,  Geracimos Rassias ,  Pamela Joan Theobald

    IPC分类号： A61K31/496 ,  C07D405/12 ,  A61P25/00 ,  A61P25/28

    CPC分类号： C07D309/12

    摘要： The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof, in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases, such as cognitive impairment, fatigue or a sleep disorder, for example in a mammal such as a human.The compound or a salt thereof has affinity for and is an antagonist and/or inverse agonist of the histamine H3 receptor.

    摘要翻译： 本发明涉及1-（1-甲基乙基）-4 - {[4-（四氢-2H-吡喃-4-基氧基）苯基]羰基}哌嗪或其药学上可接受的盐，特别是其盐酸盐和结晶 形式的盐酸盐; 制备化合物或其盐的方法; 含有它的组合物; 以及其在治疗或预防神经或精神疾病如认知障碍，疲劳或睡眠障碍中的用途，例如在哺乳动物如人中的用途。 该化合物或其盐对组胺H3受体具有亲和性，并且是拮抗剂和/或反向激动剂。

    Penicillins
    10.
    发明授权
    Penicillins 失效
    青霉素

    公开(公告)号：US3935192A

    公开(公告)日：1976-01-27

    申请号：US578262

    申请日：1975-05-16

    申请人： Harry Ferres ,  Adrian Victor Kemmenoe ,  Desmond John Best

    发明人： Harry Ferres ,  Adrian Victor Kemmenoe ,  Desmond John Best

    IPC分类号： C07D499/00 ,  C07D499/64

    CPC分类号： C07D499/00

    摘要： New penicillins and their salts and esters particularly active against Gram-negative organisms such as Pseudomonas spp., and their preparation and administration. The penicillins are active against clinically important organisms against which well-known broad spectrum penicillins are inactive and may generally be designated as aminoacyldipeptide penicillins of unusual structure and properties.

    摘要翻译： 新青霉素及其对革兰氏阴性生物体如假单胞菌属（Pseudomonas spp。）及其制剂和给药特别有活性的盐和酯。 青霉素对临床上重要的生物有活性，其中众所周知的广谱青霉素是无活性的，并且通常可以被称为具有不寻常结构和性质的氨酰三肽青霉素。