SILK POLYMER-BASED ADENOSINE RELEASE: THERAPEUTIC POTENTIAL FOR EPILEPSY
    1.
    发明申请
    SILK POLYMER-BASED ADENOSINE RELEASE: THERAPEUTIC POTENTIAL FOR EPILEPSY 有权
    基于SILK聚合物的腺苷释放酶:治疗潜能

    公开(公告)号:US20110152214A1

    公开(公告)日:2011-06-23

    申请号:US12991973

    申请日:2009-05-15

    IPC分类号: A61K31/7076 A61P25/08

    CPC分类号: A61K9/0085 A61K47/42

    摘要: This invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine, that provide for sustained, focal release of adenosine at therapeutic levels for the treatment of epilepsy and/or the prevention of epileptogenesis. An embodiment provides for a silk-based, adeno sine-releasing implant that alleviates seizures or prevents epileptogenesis. Another embodiment provides for a method of treating epilepsy or preventing epileptogenesis comprising focally administering adenosine in a sustained-release, silk-based adenosine delivery system.

    摘要翻译: 本发明涉及包含丝素蛋白生物聚合物和腺苷的持续释放制剂,其提供用于治疗癫痫治疗水平的腺苷的持续和局部释放和/或预防癫痫发生。 一个实施方案提供了一种减轻癫痫发作或预防癫痫发生的丝状,腺苷释放的植入物。 另一个实施方案提供了治疗癫痫或预防癫痫发生的方法,其包括在持续释放的基于丝的腺苷递送系统中对腺苷进行聚焦。