公开(公告)号：US20180186881A1

公开(公告)日：2018-07-05

申请号：US15859506

申请日：2017-12-30

Applicant: Development Center for Biotechnology

Inventor： Yu-Chen Yang ,  Li-Yu CHEN ,  Chia-Hua LI ,  Pei-Han TAI ,  Hong-Kai CHEN ,  Ying-Yung LOK ,  Chih-Yung HU ,  Chien-Tsun KUAN ,  Chung-Hsiun WU

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574

Abstract: An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.

公开(公告)号：US20190309092A1

公开(公告)日：2019-10-10

申请号：US16318615

申请日：2017-07-20

Applicant: DCB-USA LLC ,  Development Center for Biotechnology

Inventor： Chih-Yung HU ,  Chao-Yang HUANG ,  Yu-Jung CHEN ,  Chia-Cheng WU ,  Chien-Tsun KUAN ,  Chia-Hsiang LO ,  Hsien-Yu TSAI

IPC: C07K16/46 ,  C07K16/18 ,  C07K16/30 ,  C07K16/22 ,  C07K16/28 ,  C07K16/24 ,  C07K16/32

Abstract: The present invention provides a modified antigen-binding Fab fragment. An antigen-binding molecule comprising the antigen-binding Fab fragment and a composition comprising the molecule are also provided.