公开(公告)号：US10752688B2

公开(公告)日：2020-08-25

申请号：US15859506

申请日：2017-12-30

申请人： Development Center for Biotechnology

发明人： Yu-Chen Yang ,  Li-Yu Chen ,  Chia-Hua Li ,  Pei-Han Tai ,  Hong-Kai Chen ,  Ying-Yung Lok ,  Chih-Yung Hu ,  Chien-Tsun Kuan ,  Chung-Hsiun Wu

IPC分类号： C07K16/00 ,  C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K39/00

摘要： An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.

公开(公告)号：US20180186881A1

公开(公告)日：2018-07-05

申请号：US15859506

申请日：2017-12-30

申请人： Development Center for Biotechnology

发明人： Yu-Chen Yang ,  Li-Yu CHEN ,  Chia-Hua LI ,  Pei-Han TAI ,  Hong-Kai CHEN ,  Ying-Yung LOK ,  Chih-Yung HU ,  Chien-Tsun KUAN ,  Chung-Hsiun WU

IPC分类号： C07K16/28 ,  A61P35/00 ,  G01N33/574

摘要： An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.