公开(公告)号：US20190203192A1

公开(公告)日：2019-07-04

申请号：US15859500

申请日：2017-12-30

Applicant: Development Center for Biotechnology

Inventor： Jei-Hwa YU ,  Iok-U FONG ,  Su-Yi HSU ,  Chih-Yung HU ,  Chia-Cheng WU

IPC: C12N9/64 ,  C07K16/22 ,  C07K14/575 ,  C07K16/28 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  A61P31/00

CPC classification number: C12N9/6445 ,  A61K39/395 ,  A61K2039/505 ,  A61P25/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  C07K14/5759 ,  C07K16/22 ,  C07K16/2803 ,  C07K16/46 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

Abstract: An antibody prodrug capable of being selectively activated in a central nervous system (CNS) by protease KLK6 includes an antibody for treating a disease or disorder in the CNS; a KLK6 cleavable peptide fused to an N-terminus of a heavy chain and/or a light chain of the antibody; and a blocker fused to an N-terminus of the KLK6 cleavable peptide. The disease or disorder is a cancer, inflammatory disease, autoimmune disease, infectious disease, or neuron degeneration disease.

公开(公告)号：US20180186881A1

公开(公告)日：2018-07-05

申请号：US15859506

申请日：2017-12-30

Applicant: Development Center for Biotechnology

Inventor： Yu-Chen Yang ,  Li-Yu CHEN ,  Chia-Hua LI ,  Pei-Han TAI ,  Hong-Kai CHEN ,  Ying-Yung LOK ,  Chih-Yung HU ,  Chien-Tsun KUAN ,  Chung-Hsiun WU

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574

Abstract: An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.

公开(公告)号：US20250136709A1

公开(公告)日：2025-05-01

申请号：US18944819

申请日：2024-11-12

Applicant: Development Center for Biotechnology

Inventor： Chun-Chung LEE ,  Yu-Hsun LO ,  Chu-Bin LIAO ,  Chen-Jei HONG ,  Sih-Yu CHEN ,  Yen-Yu WU ,  Szu-Liang LAI ,  Chih-Yung HU ,  Wen-Bin KE ,  Ya-Ting JUAN ,  Kao-Jean HUANG

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.

公开(公告)号：US20230279139A1

公开(公告)日：2023-09-07

申请号：US17686666

申请日：2022-03-04

Applicant: Development Center for Biotechnology

Inventor： Chun-Chung LEE ,  Yu-Hsun LO ,  Chu-Bin LIAO ,  Chen-Jei HONG ,  Sih-Yu CHEN ,  Yen-Yu WU ,  Szu-Liang LAI ,  Chih-Yung HU ,  Wen-Bin KE ,  Ya-Ting JUAN ,  Kao-Jean HUANG

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07K16/2896 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/622 ,  A61K2039/505

Abstract: The present invention relates to a novel antibody, an antigen-binding fragment thereof and the uses of the antibody and fragment, wherein the antibody and the fragment comprise specific complementarity-determining regions (CDRs) and/or specifically bind to human CD73 at specific epitopes.

公开(公告)号：US20190309092A1

公开(公告)日：2019-10-10

申请号：US16318615

申请日：2017-07-20

Applicant: DCB-USA LLC ,  Development Center for Biotechnology

Inventor： Chih-Yung HU ,  Chao-Yang HUANG ,  Yu-Jung CHEN ,  Chia-Cheng WU ,  Chien-Tsun KUAN ,  Chia-Hsiang LO ,  Hsien-Yu TSAI

IPC: C07K16/46 ,  C07K16/18 ,  C07K16/30 ,  C07K16/22 ,  C07K16/28 ,  C07K16/24 ,  C07K16/32

Abstract: The present invention provides a modified antigen-binding Fab fragment. An antigen-binding molecule comprising the antigen-binding Fab fragment and a composition comprising the molecule are also provided.