公开(公告)号：US20040199059A1

公开(公告)日：2004-10-07

申请号：US10646333

申请日：2003-08-22

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Victoria Carr-Brendel ,  Paul V. Neale ,  Laura A. Martinson

IPC: A61B005/00

CPC classification number: A61B5/6882 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/415 ,  A61B5/418 ,  A61B2562/187

Abstract: An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.

Abstract translation: 一种用于测量体液中诸如葡萄糖的分析物的浓度的植入式传感器，其包括具有适于在所述传感器和所述体液之间输送分析物的感测区域的身体，其中所述感测区域位于弯曲部分上 使得当异物体胶囊围绕传感器形成时，异物胶囊朝向感测区域施加收缩力。 身体部分或完全弯曲，部分或完全覆盖有用于支撑组织向内生长的锚固材料，并被设计用于皮下组织植入。 几何设计，包括曲率，形状和其他因素最大限度地减少传感区域的慢性炎症反应，并有助于改善体内传感器的性能。

公开(公告)号：US20030023317A1

公开(公告)日：2003-01-30

申请号：US09916386

申请日：2001-07-27

Applicant: Dexcom, Inc.

Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

IPC: A61F002/02

CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

公开(公告)号：US20040186362A1

公开(公告)日：2004-09-23

申请号：US10768889

申请日：2004-01-29

Applicant: Dexcom, Inc.

Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

IPC: A61B005/00

CPC classification number: A61B5/14735 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2562/02 ,  A61L31/10 ,  A61L31/14 ,  Y10T428/249921

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

公开(公告)号：US20030032874A1

公开(公告)日：2003-02-13

申请号：US09916711

申请日：2001-07-27

Applicant: Dexcom, Inc.

Inventor： Rathbun Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

IPC: A61B005/05

CPC classification number: G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

Abstract translation: 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。