公开(公告)号：US09029507B2

公开(公告)日：2015-05-12

申请号：US13985416

申请日：2012-02-14

申请人： Dhananjay Govind Sathe ,  Avinash Venkatraman Naidu ,  Subramanian Sundaram ,  Anindya Sibnath Bhattacharyya ,  Rakesh Shekhawat ,  Divya Lal Saksena ,  Sukumar Ramanujam ,  Sanjay Vyankatrao Patil

发明人： Dhananjay Govind Sathe ,  Avinash Venkatraman Naidu ,  Subramanian Sundaram ,  Anindya Sibnath Bhattacharyya ,  Rakesh Shekhawat ,  Divya Lal Saksena ,  Sukumar Ramanujam ,  Sanjay Vyankatrao Patil

IPC分类号： C07K1/00 ,  C12Q1/37 ,  C07K2/00 ,  C07K14/00 ,  C08G69/10 ,  G01N30/02 ,  A61K38/00

CPC分类号： C12Q1/37 ,  A61K38/00 ,  C07K2/00 ,  C07K14/001 ,  C08G69/10 ,  G01N30/02

摘要： The present invention relates to analytical methods such as molecular weight determination of polypeptide, in particular Glatiramer acetate. The present invention further relates to an improved process for preparation of polypeptides or pharmaceutically acceptable salts thereof, particularly Glatiramer acetate also known as Copolymer-1. The present invention further relates to characterization of Glatiramer acetate by peptide mapping.

摘要翻译： 本发明涉及分析方法，例如多肽的分子量测定，特别是乙酸格拉默。 本发明还涉及制备多肽或其药学上可接受的盐，特别是也称为共聚物-1的乙酸格拉默酮的改进方法。 本发明还涉及通过肽图谱表征乙酸格拉默。