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    METHODS, PLANTS AND COMPOSITIONS FOR OVERCOMING NUTRIENT SUPPRESSION OF MYCORRHIZAL SYMBIOSIS
    1.
    发明公开
    METHODS, PLANTS AND COMPOSITIONS FOR OVERCOMING NUTRIENT SUPPRESSION OF MYCORRHIZAL SYMBIOSIS 审中-公开

    公开(公告)号：US20240229060A1

    公开(公告)日：2024-07-11

    申请号：US17802506

    申请日：2021-02-26

    Applicant: Cambridge Enterprise Limited

    Inventor： Doris ALBINSKY ,  Xinran LI ,  Giles Edward Dixon OLDROYD ,  Jongho SUN

    IPC: C12N15/82 ,  C07K2/00

    CPC classification number: C12N15/8261 ,  C07K2/00

    Abstract: Aspects of the present disclosure relate to methods of cultivating genetically altered plants with increased activity of one or more of a NODULATION SIGNALING PATHWAY 1 (NSP1) protein or a NODULATION SIGNALING PATHWAY 2 (NSP2) protein that have increased mycorrhization and/or promoted symbiotic responses under high phosphate and/or high nitrate conditions. Further aspects of the present disclosure relate to methods of cultivating genetically altered plants with increased activity of a C-TERMINALLY ENCODED PEPTIDE (CEP peptide) that have increased mycorrhization and/or promoted symbiotic responses under high phosphate and/or high nitrate conditions. In addition, aspects of the present disclosure relate to methods of cultivating these plants that include exogenous application of strigolactones, karrikins, and/or CEP peptides to increase mycorrhization and/or promote symbiotic responses under specific nutrient conditions.

    DRUG COMPLEX
    8.
    发明申请
    DRUG COMPLEX 审中-公开

    公开(公告)号：US20180264124A1

    公开(公告)日：2018-09-20

    申请号：US15738919

    申请日：2016-06-25

    Applicant: Shimadzu Corporation

    Inventor： Ikuo FUJII

    IPC: A61K47/64 ,  C07K14/00 ,  A61K38/07 ,  A61P35/00

    CPC classification number: A61K47/64 ,  A61K38/07 ,  A61K47/42 ,  A61K47/50 ,  A61P35/00 ,  C07K2/00 ,  C07K14/00

    Abstract: [Problem to be solved] To provide a drug delivery system capable of delivering a drug into a cell expressing a VEGF receptor.[Solution] Provided is a VEGF-binding peptide-drug complex in which a drug is bound to a C-terminal amino acid and/or an N-terminal amino acid of a VEGF-binding peptide and is incorporated into a VEGF receptor-expressing cell by endocytosis of a VEGF receptor, the VEGF-binding peptide having a helix-loop-helix structure including an A block that includes a peptide forming an α-helix structure and is positioned on an N-terminal side, a C block that includes a peptide forming an α-helix structure and is positioned on a C-terminal side, and a B block that includes a peptide linking the A block and the C block by a covalent bond.

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