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1.发明申请公开(公告)号：US20080293768A1
公开(公告)日：2008-11-27
申请号：US11909489
申请日：2006-03-24
IPC分类号： A61K31/4545 , C07D409/12 , C07D409/14 , A61P9/00 , A61K31/4436
CPC分类号： C07H15/203 , C07H17/02
摘要： The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.
摘要翻译： 本发明涉及新的5-硫代木糖化合物，优选5-羟基吡喃糖型衍生物，其制备方法及其作为特别用于治疗或预防血栓形成或心脏功能不全的药物的活性成分的用途。
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公开(公告)号：US20090118325A1
公开(公告)日：2009-05-07
申请号：US12352382
申请日：2009-01-12
IPC分类号： A61K31/437 , C07D409/02 , A61K31/428 , A61K31/423 , C07D471/02
摘要： 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.
摘要翻译： 5-硫代羟基化合物，特别是5-羟基吡喃糖化合物，其制备方法及其用于治疗和/或抑制血栓形成，特别是静脉血栓形成的用途。 化合物对应于式I：其中五草酰基代表游离或取代的5-硫代-β-D-吡喃木糖基; R'，R“和R”'各自独立地表示氢原子，C 2 -C 6酰基或其两个相邻的一个形成1-甲基亚乙基桥; X1和X2各自表示碳或氮; Y1和Y2各自独立地表示碳，氮，硫或氧，条件是如果Y2表示氧或硫，则Y1表示碳或氮; R 1，R 2，R 3，R 4和R 5各自独立地表示氢，COOR 6基团，其中R 6表示氢或任选被苯环，卤素原子或-COOR 6基团取代的C 1 -C 4烷基; C1-C4烷氧基; C1-C6酰基; 苯甲酰基或苯环; 和这些化合物的加成盐和/或活性代谢物。
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公开(公告)号：US20090182013A1
公开(公告)日：2009-07-16
申请号：US12411783
申请日：2009-03-26
IPC分类号： A61K31/4436 , C07D409/12 , A61P7/02
CPC分类号： C07H17/02
摘要： The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.
摘要翻译： 本发明涉及5-硫代二糖的新化合物，优选5-硫代吡喃葡糖型衍生物及其制备方法及其作为主要用于治疗或抑制血栓形成或心力衰竭或血栓栓塞性疾病的药物活性成分的用途 。
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公开(公告)号：US20090186840A1
公开(公告)日：2009-07-23
申请号：US12411765
申请日：2009-03-26
IPC分类号： C07H15/20 , A61K31/7034 , A61P9/00
CPC分类号： C07H15/203
摘要： Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.
摘要翻译： 5-硫代羟基吡喃糖的化合物，优选5-硫代吡喃葡萄糖型的衍生物，制备这些化合物的方法，以及这些化合物作为有效成分在药物组合物中的用途，其特别用于治疗或抑制血栓形成或心力衰竭 或血栓栓塞性疾病状态。
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公开(公告)号：US07652032B2
公开(公告)日：2010-01-26
申请号：US12352382
申请日：2009-01-12
IPC分类号： A61K31/4355 , C07D498/04
摘要： 5-thioxylose compounds, especially 5-thioxylopyranose compounds, a process for their preparation, and their use for treating and/or inhibiting thromboses, especially venous thromboses. The compounds correspond to formula I: in which the pentapyranosyl group represents a free or substituted 5-thio-β-D-xylopyranosyl group; R′, R″ and R′″ each independently represent a hydrogen atom, a C2-C6 acyl group, or two adjacent ones of them form a 1-methylethylidene bridge; X1 and X2 each represent carbon or nitrogen; Y1 and Y2 each independently represent carbon, nitrogen, sulfur or oxygen, with the proviso that if Y2 represents oxygen or sulfur, then Y1 represents carbon or nitrogen; R1, R2, R3, R4 and R5 each independently represent hydrogen, a COOR6 group where R6 represents hydrogen or a C1-C4 alkyl group optionally substituted by a phenyl ring, a halogen atom or a —COOR6 group; a C1-C4 alkoxy group; a C1-C6 acyl group; a benzoyl group or a phenyl ring; and the addition salts and/or active metabolites of such compounds.
摘要翻译： 5-硫代羟基化合物，特别是5-羟基吡喃糖化合物，其制备方法及其用于治疗和/或抑制血栓形成，特别是静脉血栓形成的用途。 化合物对应于式I：其中五草酰基代表游离或取代的5-硫代-β-D-吡喃木糖基; R'，R“和R”'各自独立地表示氢原子，C 2 -C 6酰基或其两个相邻的一个形成1-甲基亚乙基桥; X1和X2各自表示碳或氮; Y1和Y2各自独立地表示碳，氮，硫或氧，条件是如果Y2表示氧或硫，则Y1表示碳或氮; R 1，R 2，R 3，R 4和R 5各自独立地表示氢，COOR 6基团，其中R 6表示氢或任选被苯环，卤素原子或-COOR 6基团取代的C 1 -C 4烷基; C1-C4烷氧基; C1-C6酰基; 苯甲酰基或苯环; 和这些化合物的加成盐和/或活性代谢物。
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公开(公告)号：US08148407B2
公开(公告)日：2012-04-03
申请号：US11909489
申请日：2006-03-24
IPC分类号： A61K31/4436 , C07D409/12
CPC分类号： C07H15/203 , C07H17/02
摘要： The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.
摘要翻译： 本发明涉及新的5-硫代木糖化合物，优选5-羟基吡喃糖型衍生物，其制备方法及其作为特别用于治疗或预防血栓形成或心脏功能不全的药物的活性成分的用途。
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公开(公告)号：US08013010B2
公开(公告)日：2011-09-06
申请号：US12411765
申请日：2009-03-26
IPC分类号： A61K31/382 , C07D335/02
CPC分类号： C07H15/203
摘要： Compounds of 5-thioxylopyranose, preferably derivatives of the 5-thioxilopyranose type, a method for preparing such compounds, and the use of such compounds as an active ingredient in pharmaceutical compositions which are useful, in particular, for treating or inhibiting thrombosis or heart failure or thromboembolic disease states.
摘要翻译： 5-硫代羟基吡喃糖的化合物，优选5-硫代吡喃葡萄糖型的衍生物，制备这些化合物的方法，以及这些化合物作为有效成分在药物组合物中的用途，其特别用于治疗或抑制血栓形成或心力衰竭 或血栓栓塞性疾病状态。
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8.发明授权Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain 有权苯磺酰胺衍生物，其用于治疗疼痛的生产方法和用途公开(公告)号：US07538111B2
公开(公告)日：2009-05-26
申请号：US10549546
申请日：2004-03-24
申请人： Martine Barth , Michel Bondoux , Pierre Dodey , Christine Massardier , Didier Thomas , Jean-Michel Luccarini
发明人： Martine Barth , Michel Bondoux , Pierre Dodey , Christine Massardier , Didier Thomas , Jean-Michel Luccarini
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D295/185 , C07D211/26 , C07D211/58 , C07D451/02 , C07D453/02
摘要： The present invention concerns novel benzenesulphonamide compounds, defined by formula I. Therapeutic compositions comprising the benzenesulphonamide compounds of the invention or salts thereof and methods for producing the benzenesulphonamide compounds of the invention are also disclosed. The benzenesulphonamide compounds of the invention or salts thereof are useful for treating pain, such as hyperalgesia and major algesia.
摘要翻译： 本发明涉及由式I定义的新型苯磺酰胺化合物。还公开了包含本发明的苯磺酰胺化合物或其盐的治疗组合物和用于制备本发明的苯磺酰胺化合物的方法。 本发明的苯磺酰胺化合物或其盐可用于治疗疼痛，例如痛觉过敏和主要的痛觉。
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9.发明申请Benzenesulphonamide derivatives, method for production and use thereof for treatment of pain 有权苯磺酰胺衍生物，其用于治疗疼痛的生产方法和用途公开(公告)号：US20060178360A1
公开(公告)日：2006-08-10
申请号：US10549546
申请日：2004-03-24
申请人： Martine Barth , Michel Bondoux , Pierre Dodey , Christine Massardier , Didier Thomas , Jean-Michel Luccarini
发明人： Martine Barth , Michel Bondoux , Pierre Dodey , Christine Massardier , Didier Thomas , Jean-Michel Luccarini
IPC分类号： A61K31/55 , A61K31/551 , A61K31/496 , A61K31/445 , A61K31/454 , C07D403/02
CPC分类号： C07D295/185 , C07D211/26 , C07D211/58 , C07D451/02 , C07D453/02
摘要： The present invention concerns novel benzenesulphonamide compounds, defined by formula I and the description, their method of preparation and their use in therapy.
摘要翻译： 本发明涉及由式I定义的新型苯磺酰胺化合物及其描述，其制备方法及其在治疗中的应用。
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公开(公告)号：US08093394B2
公开(公告)日：2012-01-10
申请号：US12411783
申请日：2009-03-26
IPC分类号： C07H17/02 , A61K31/44 , C07D409/12 , C07D409/14
CPC分类号： C07H17/02
摘要： The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.
摘要翻译： 本发明涉及5-硫代二糖的新化合物，优选5-硫代吡喃葡糖型衍生物及其制备方法及其作为主要用于治疗或抑制血栓形成或心力衰竭或血栓栓塞性疾病的药物活性成分的用途 。
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