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1.NOVEL 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO[4,3-C] ISOQUINOLINE COMPOUNDS 审中-公开
标题翻译: 新的3,4,4A,10B-四氢-1H-苯并[4,3-C]异喹啉化合物公开(公告)号:US20140113877A1
公开(公告)日:2014-04-24
申请号:US14124446
申请日:2012-06-12
申请人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
发明人: Dieter Flockerzi , Alexander Mann , Thomas Stengel , Harald Ohmer , Ulrich Kautz , Steffen Weinbrenner , Stefan Fischer , Hermann Tenor , Christof Zitt , Armin Hatzelmann , Torsten Dunkern , Christian Hesslinger , Clemens Braun , Ewald Benediktus , Andreas Pahl , Raimund Kuelzer , Degenhard Marx
IPC分类号: C07D519/00 , A61K45/06 , A61K31/519
CPC分类号: C07D519/00 , A61K31/519 , A61K45/06 , C07D495/04
摘要: The compounds of formula (1) in which A, X, R1, R2, R3 and R7 have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译: 其中A,X,R1,R2,R3和R7具有说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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2.
公开(公告)号:US20140112945A1
公开(公告)日:2014-04-24
申请号:US14125187
申请日:2012-06-12
申请人: Thomas Stengel , Thomas Maier , Alexander Mann , Josef Stadlwieser , Dieter Flockerzi , Andreas Pahl , Ewald Benediktus , Manuela Hessmann , Tobias Kanacher , Ragna Hussong , Christof Zitt , Hans Christof Holst , Rolf-Peter Hummel , Martin Viertelhaus , Hermann Tenor , Torsten Dunkern , Armin Hatzelmann , Christian Hesslinger
发明人: Thomas Stengel , Thomas Maier , Alexander Mann , Josef Stadlwieser , Dieter Flockerzi , Andreas Pahl , Ewald Benediktus , Manuela Hessmann , Tobias Kanacher , Ragna Hussong , Christof Zitt , Hans Christof Holst , Rolf-Peter Hummel , Martin Viertelhaus , Hermann Tenor , Torsten Dunkern , Armin Hatzelmann , Christian Hesslinger
IPC分类号: A61K31/519 , A61K45/06 , C07D487/04
CPC分类号: C07D487/04 , A61K31/519 , A61K45/06
摘要: The compounds of formula (1) in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and type 5 phosphodiesterase.
摘要翻译: 其中R1,R7,R8,R9,R10,R17,R18,R19,R20和m具有如说明书中给出的含义的式(1)化合物是4型和5型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US08927557B2
公开(公告)日:2015-01-06
申请号:US13390940
申请日:2010-08-24
申请人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Torsten Dunkern , Ewald Benediktus , Andreas Pahl , Ragna Hussong , Olaf Nimz , Matthias Mueller , Martin Viertelhaus
发明人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Torsten Dunkern , Ewald Benediktus , Andreas Pahl , Ragna Hussong , Olaf Nimz , Matthias Mueller , Martin Viertelhaus
IPC分类号: C07D487/04 , A61K31/519 , A61P9/08 , A61P1/16 , A61P9/12
CPC分类号: C07D487/04 , A61K2300/00
摘要: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
摘要翻译: 式(I)化合物,其中R 1,R 2,R 21,R 22,R 23,R 24,Y和R 3具有本说明书中给出的含义,其盐,化合物及其盐的立体异构体是有效的抑制剂 5型磷酸二酯酶。
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公开(公告)号:US20120142633A1
公开(公告)日:2012-06-07
申请号:US13390942
申请日:2010-08-24
申请人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Alexander Sudau , Torsten Dunkern , Ragna Hussong , Ewald Benediktus , Andreas Pahl
发明人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Alexander Sudau , Torsten Dunkern , Ragna Hussong , Ewald Benediktus , Andreas Pahl
IPC分类号: A61K31/437 , C07F7/02 , A61K31/695 , A61P1/16 , A61P11/06 , A61P11/08 , A61P9/12 , C07D471/04 , A61P11/00
CPC分类号: C07D471/04
摘要: The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
摘要翻译: 式(I)的化合物,其中R 1,R 21,R 22,R 23,R 24,Y和R 3具有在说明书中给出的含义,其盐,化合物及其盐的立体异构体是有效的类型的抑制剂 5磷酸二酯酶。
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公开(公告)号:US08816085B2
公开(公告)日:2014-08-26
申请号:US13390942
申请日:2010-08-24
申请人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Alexander Sudau , Torsten Dunkern , Ragna Hussong , Ewald Benediktus , Andreas Pahl
发明人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Alexander Sudau , Torsten Dunkern , Ragna Hussong , Ewald Benediktus , Andreas Pahl
IPC分类号: A61K31/437 , C07D471/04
CPC分类号: C07D471/04
摘要: The compounds of Formula (I), wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
摘要翻译: 式(I)的化合物,其中R 1,R 21,R 22,R 23,R 24,Y和R 3具有在说明书中给出的含义,其盐,化合物及其盐的立体异构体是有效的类型的抑制剂 5磷酸二酯酶。
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公开(公告)号:US20120149721A1
公开(公告)日:2012-06-14
申请号:US13390940
申请日:2010-08-24
申请人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Torsten Dunkern , Ewald Benediktus , Andreas Pahl , Ragna Hussong , Olaf Nimz , Matthias Mueller , Martin Viertelhaus
发明人: Josef Stadlwieser , Beate Schmidt , Heiko Bernsmann , Torsten Dunkern , Ewald Benediktus , Andreas Pahl , Ragna Hussong , Olaf Nimz , Matthias Mueller , Martin Viertelhaus
IPC分类号: A61K31/519 , A61P11/00 , A61P1/16 , A61P11/08 , A61P9/12 , C07D487/04 , A61P11/06
CPC分类号: C07D487/04 , A61K2300/00
摘要: The compounds of Formula (I), wherein R1, R2, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the stereoisomers of the compounds and the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
摘要翻译: 式(I)化合物,其中R 1,R 2,R 21,R 22,R 23,R 24,Y和R 3具有本说明书中给出的含义,其盐,化合物及其盐的立体异构体是有效的抑制剂 5型磷酸二酯酶。
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