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    Supramolecular pairing system, its preparation and use
    4.
    发明授权
    Supramolecular pairing system, its preparation and use 有权
    超分子配对体系，其制备和应用

    公开(公告)号：US06689884B1

    公开(公告)日：2004-02-10

    申请号：US09509040

    申请日：2000-08-03

    申请人： Christian Miculka ,  Norbert Windhab ,  Albert Eschenmoser ,  Stefan Scherer ,  Gerhard Quinkert

    发明人： Christian Miculka ,  Norbert Windhab ,  Albert Eschenmoser ,  Stefan Scherer ,  Gerhard Quinkert

    IPC分类号： C07D23900

    CPC分类号： C12Q1/68

    摘要： The invention relates to a compound of formula (I), wherein R1 is NR3R4, OR3 or SR3 with R3 and R4 being H or CnH2n+1 independently of each other and being the same or different, n being a whole number from 1 to 12; R2 is equal to CmH2m—C(X)—Y with X being ═O, ═S or ═N, Y being equal to OR3, NR3R4 or SR3, R3 and R4 having the same meaning given above, and m being a whole number from 1 to 4; or R2 is equal to CmH2m—Z—Y′ with Z being a sulfonyl, phosphonyl, ether or amine group, Y′ being equal to H, CnH2n+1, OR3, NR3R4 or SR3 then Z is sulphonyl or phosphonyl group, n, R3 and R4 having the meaning given above, and Y′ being equal to CnH2n+1 when Z is an ether or an amine group; A, B, and D are the same or different and mean CR5R6, O, NR7 ou S independently of each other with R5, R6 and R7 being H or CnH2n+1, independently of each other, n having the meaning given above; and C is equal to CR8 or N with R8 having the meaning of R5 independently, A—B, B—C or C—D not being two identical heteroatoms; and nucleobase means thymine, uracile, adenine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.

    摘要翻译： 本发明涉及式（I）化合物，其中R 1为NR 3 R 4，OR 3或SR 3，R 3和R 4为H或C n H 2n +1彼此独立且相同或不同，n为1至12的整数; R 2等于CmH2m-C（X）-Y，其中X为= O，= S或= N，Y等于OR 3，NR 3 R 4或SR 3， R 3和R 4具有上述相同的含义，m为1至4的整数; 或R 2等于C m H 2 m-Z Y'，其中Z是磺酰基，膦酰基，醚或胺基，Y'等于H，C n H 2n + 1，OR 3，NR 3 R 4或 当Z为醚或胺基时，Z为磺酰基或膦酰基，n，R 3和R 4具有上述含义，Y'等于C n H 2n + 1; A，B和D相同或不同，并且R 5，R 6和R 7独立地为CR 5，R 6和R 7独立地为CR 5 R 6，O，NR 7 H或C n H 2n + 1彼此独立地具有上述含义的n; 并且C等于CR 8或N，其中R 8独立地具有R 5的含义，A-B，B-C或C-D不是两个相同的杂原子; 核碱基是指胸腺嘧啶，尿嘧啶，腺嘌呤，胞嘧啶，鸟嘌呤，异胞嘧啶，异鸟嘌呤，黄嘌呤或次黄嘌呤。 本发明还涉及一种制备这些衍生物的方法及其在配对和/或测试系统中的用途。