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    Indolyl-3-glyoxylic acid derivatives having antitumor action
    3.
    发明授权
    Indolyl-3-glyoxylic acid derivatives having antitumor action 有权
    具有抗肿瘤作用的吲哚基-3-乙醛酸衍生物

    公开(公告)号：US06232327B1

    公开(公告)日：2001-05-15

    申请号：US09285058

    申请日：1999-04-02

    申请人： Bernd Nickel ,  Istvan Szelenyi ,  Jürgen Schmidt ,  Peter Emig ,  Dietmar Reichert ,  Eckhard Günther ,  Kay Brune

    发明人： Bernd Nickel ,  Istvan Szelenyi ,  Jürgen Schmidt ,  Peter Emig ,  Dietmar Reichert ,  Eckhard Günther ,  Kay Brune

    IPC分类号： A61K31435

    CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  C07D209/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.

    摘要翻译： 本发明涉及通式I的N-取代吲哚-3-乙醛酰胺作为抗肿瘤剂，并且具有抗肿瘤作用的药物组合物的用途，其特征在于，如果适用，其含有至少一种通式1的化合物 还以生理上可耐受的酸加成盐或N-氧化物的形式。 此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和 片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。

    Indolyl-3-glyoxylic acid derivatives having antitumor action
    4.
    发明授权
    Indolyl-3-glyoxylic acid derivatives having antitumor action 失效
    具有抗肿瘤作用的吲哚基-3-乙醛酸衍生物

    公开(公告)号：US07579365B2

    公开(公告)日：2009-08-25

    申请号：US10309204

    申请日：2002-12-04

    申请人： Bernd Nickel ,  Istvan Szelenyi ,  Jürgen Schmidt ,  Peter Emig ,  Dietmar Reichert ,  Eckhard Günther ,  Kay Brune ,  Guillaume Le Baut

    发明人： Bernd Nickel ,  Istvan Szelenyi ,  Jürgen Schmidt ,  Peter Emig ,  Dietmar Reichert ,  Eckhard Günther ,  Kay Brune ,  Guillaume Le Baut

    IPC分类号： A61K31/44 ,  C07D401/00

    CPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  C07D209/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

    摘要： The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.

    摘要翻译： 本发明涉及通式I的N-取代的吲哚-3-乙醛酰胺作为抗肿瘤剂和具有抗肿瘤作用的药物组合物的用途，其特征在于其含有至少一种通式1的化合物，如果 也适用于生理上可耐受的酸加成盐或N-氧化物的形式。 此外，本发明还包括抗肿瘤剂，其包含根据通式1的一种或多种N-取代的吲哚-3-乙醛酰胺作为活性化合物，以及如果合适的话，其生理上可耐受的酸加成盐，以及如果可能的话，N-氧化物和 片剂，包衣片剂，胶囊，输注溶液或安瓿，栓剂，贴剂，可通过吸入，悬浮液，霜剂和软膏使用的粉末制剂的药学上可用的载体和/或稀释剂或辅助物质。

    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action
    10.
    发明授权
    Substituted N-benzylindol-3-ylglyoxylic acid derivatives having antitumor action 有权

    公开(公告)号：US06432987B1

    公开(公告)日：2002-08-13

    申请号：US09736431

    申请日：2000-12-15

    申请人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    发明人： Eckhard Gunther ,  Peter Emig ,  Dietmar Reichert ,  Guillaume Le Baut ,  Bernd Nickel ,  Gerald Bacher

    IPC分类号： A01N4340

    摘要： The invention relates to novel, substituted N-benzyl-indol-3-ylglyoxylic acid derivatives of the following formula and their use for the treatment of oncoses The invention further relates to their physiologically tolerable acid addition salts and if possible their N-oxides. In addition, the invention relates to pharmaceutical preparations containing at least one of the compounds of the abovementioned formula or their salts or N-oxides with physiologically tolerable inorganic or organic acids and, if appropriate, pharmaceutically utilizable vehicles and/or diluents or excipients and also administration forms of the compounds of the abovementioned formula containing at least one of the compounds of this formula or their salts in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments