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公开(公告)号:US20120178912A1
公开(公告)日:2012-07-12
申请号:US13424179
申请日:2012-03-19
IPC分类号: C07K14/705 , C07K16/28 , C07H21/04
CPC分类号: C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
摘要翻译: 公开了分离的受体,编码这些受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。 受体也可用于筛选其抑制剂。
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公开(公告)号:US20110086033A1
公开(公告)日:2011-04-14
申请号:US12850368
申请日:2010-08-04
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要: Methods for inhibiting osteoclastogenesis by administering a soluble RANK polypeptide are disclosed. Such methods can be used to treat a variety of different cancers, including bone cancer, multiple myeloma, melanoma, breast cancer, squamous cell carcinoma, lung cancer, prostate cancer, hematologic cancers, head and neck cancer and renal cancer.
摘要翻译: 公开了通过施用可溶性RANK多肽来抑制破骨细胞发生的方法。 这些方法可用于治疗各种不同的癌症,包括骨癌,多发性骨髓瘤,黑素瘤,乳腺癌,鳞状细胞癌,肺癌,前列腺癌,血液癌,头颈癌和肾癌。
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公开(公告)号:US20110200990A1
公开(公告)日:2011-08-18
申请号:US13092718
申请日:2011-04-22
申请人: Dirk M. ANDERSON
发明人: Dirk M. ANDERSON
CPC分类号: C07K16/241 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/70578 , C07K14/7151 , C07K16/2875 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/73 , C12Q1/6876
摘要: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
摘要翻译: 公开了分离的受体,编码这些受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。 受体也可用于筛选其抑制剂。
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公开(公告)号:US20090004196A1
公开(公告)日:2009-01-01
申请号:US12137397
申请日:2008-06-11
IPC分类号: A61K39/395 , A61K38/16 , A61P35/04
CPC分类号: C07K14/70575 , A61K38/00 , A61K2039/505 , C07K14/70578 , C07K2319/00 , C07K2319/30 , C07K2319/73 , Y10S530/866
摘要: Methods for inhibiting osteoclastogenesis by administering a soluble RANK polypeptide are disclosed. Such methods can be used to treat a variety of different cancers, including bone cancer, multiple myeloma, melanoma, breast cancer, squamous cell carcinoma, lung cancer, prostate cancer, hematologic cancers, head and neck cancer and renal cancer.
摘要翻译: 公开了通过施用可溶性RANK多肽来抑制破骨细胞发生的方法。 这些方法可用于治疗各种不同的癌症,包括骨癌,多发性骨髓瘤,黑素瘤,乳腺癌,鳞状细胞癌,肺癌,前列腺癌,血液癌,头颈癌和肾癌。
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