公开(公告)号：US5880266A

公开(公告)日：1999-03-09

申请号：US821809

申请日：1997-03-21

申请人： Dirk R. De Buyser

发明人： Dirk R. De Buyser

IPC分类号： A23J1/16 ,  A23J1/06 ,  A23J3/12 ,  A23L5/20 ,  A23L5/49 ,  A23L13/40 ,  A23L13/60 ,  A61K35/14 ,  A23J1/02

CPC分类号： A23J3/12 ,  A23J1/06 ,  A23L13/424 ,  A23L13/60 ,  A23L13/65 ,  A23L5/49

摘要： The invention relates to new protein derivatives of blood, blood-protein containing raw materials and hemoglobin, and more particularly to processed globin products, and to processes for producing these products. The processed globin products have an isoelectric point at a pH value below 5.5, an iron content of less than 1000 ppm, a ratio of His : Lys between 0.6 and 1.5, a Tyrosine content of at least 0.5% by weight, a Methionine content of at least 0.5% by weight, and a Lysine content of at least 5% by weight. The method for the production of the processed globin products according to the invention comprises treating the starting material at a pH above 12 and an the oxidizing treatment step the pH is kept below 12 while maintaining the temperature below 50.degree. C.

摘要翻译： 本发明涉及新的血液蛋白衍生物，含血液蛋白质的原料和血红蛋白，更具体地说涉及处理过的珠蛋白产品，以及生产这些产品的方法。 经处理的球蛋白产物的pH值低于5.5，铁含量小于1000ppm，His：Lys的比例在0.6和1.5之间，酪氨酸含量至少为0.5重量％，甲硫氨酸含量为 至少0.5重量％，赖氨酸含量至少为5重量％。 根据本发明的生产加工球蛋白产品的方法包括在高于12的pH下处理原料，并且将氧化处理步骤的pH保持在12以下，同时保持温度低于50℃。