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1.发明申请miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention 审中-公开miR-10调节基因和途径作为治疗干预的目标公开(公告)号：US20090192114A1
公开(公告)日：2009-07-30
申请号：US12340329
申请日：2008-12-19
CPC分类号： C12N15/113 , C12N2310/141 , C12N2320/11 , C12N2320/12
摘要： The present invention concerns methods and compositions for identifying genes or genetic pathways modulated by miR-10, using miR-10 to modulate a gene or gene pathway, using this profile in assessing the condition of a patient and/or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于鉴定miR-10调节的基因或遗传途径的方法和组合物，其使用miR-10调节基因或基因途径，使用该分布在评估患者的状况和/或以适当的方式治疗患者时 miRNA。
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公开(公告)号：US20120282696A1
公开(公告)日：2012-11-08
申请号：US13440743
申请日：2012-04-05
申请人： Charles D. Johnson , Mike W. Byrom , Andreas G. Bader , Frank J. Slack , David Brown , Dmitriy Ovcharenko , Kevin Kelnar
发明人： Charles D. Johnson , Mike W. Byrom , Andreas G. Bader , Frank J. Slack , David Brown , Dmitriy Ovcharenko , Kevin Kelnar
IPC分类号： C12N5/09
CPC分类号： C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention concerns methods and compositions for treating or assessing treatment of diseases related to mis-expression of genes or genetic pathways that can be modulated by let-7. Methods may include evaluating patients for genes or genetic pathways modulated by let-7, and/or using an expression profile to assess the condition of a patient or treating the patient with an appropriate miRNA.
摘要翻译： 本发明涉及用于治疗或评估与由let-7调节的基因或遗传途径的错误表达有关的疾病的治疗方法和组合物。 方法可以包括评价患者的由let-7调节的基因或遗传途径，和/或使用表达谱来评估患者的状况或用合适的miRNA治疗患者。
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3.发明授权公开(公告)号：US08173611B2
公开(公告)日：2012-05-08
申请号：US11273640
申请日：2005-11-14
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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公开(公告)号：US08946177B2
公开(公告)日：2015-02-03
申请号：US13299255
申请日：2011-11-17
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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5.发明申请METHODS AND COMPOSITIONS INVOLVING MIRNA AND MIRNA INHIBITOR MOLECULES 审中-公开涉及MIRNA和MIRNA抑制剂分子的方法和组合物公开(公告)号：US20110313025A1
公开(公告)日：2011-12-22
申请号：US13190232
申请日：2011-07-25
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： A61K31/713 , A61P35/00 , C12N5/09
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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公开(公告)号：US20090092974A1
公开(公告)日：2009-04-09
申请号：US11953606
申请日：2007-12-10
申请人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
发明人： Tim Davison , Dmitriy Ovcharenko , Jeffrey Shelton , Kevin Kelnar , David Brown
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/178 , C12Q2525/207
摘要： The present invention concerns methods and compositions for identifying a miRNA profile for acute myeloid leukemia (AML), and using the profile in assessing the condition of a patient.
摘要翻译： 本发明涉及用于鉴定急性骨髓性白血病（AML）的miRNA谱的方法和组合物，并且在评估患者状况时使用该分布。
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公开(公告)号：US08058250B2
公开(公告)日：2011-11-15
申请号：US11837488
申请日：2007-08-10
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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8.发明授权公开(公告)号：US07960359B2
公开(公告)日：2011-06-14
申请号：US11837490
申请日：2007-08-10
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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9.发明申请公开(公告)号：US20090176723A1
公开(公告)日：2009-07-09
申请号：US11273640
申请日：2005-11-14
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号： A61K31/7105 , C07H21/02 , C40B40/08 , C12Q1/68 , C12N5/06
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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10.发明申请公开(公告)号：US20080171715A1
公开(公告)日：2008-07-17
申请号：US11837488
申请日：2007-08-10
申请人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
发明人： David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
CPC分类号： C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
摘要翻译： 本发明涉及使用合成核酸分子将miRNA活性或功能引入细胞的方法和组合物。 此外，本发明涉及用于鉴定具有与治疗，诊断和预后应用相关的特定细胞功能的miRNA的方法和组合物，其中在文库筛选测定中使用合成的miRNA和/或miRNA抑制剂。
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