专利检索 ap:("Dominique P. Bridon" OR "Robert S. Dufresne" OR "Nisssab Boudjellab" OR "Martin Robitaille" OR "Peter G. Milner") AND inv:"Nisssab Boudjellab" 第 1 页

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发明授权
Modified human immunodeficiency virus anti-fusogenic GP41 peptides comprising a maleimide-containing group 失效
标题翻译：包含含马来酰亚胺基团的修饰的人免疫缺陷病毒抗融合GP41肽

公开(公告)号：US07608271B2

公开(公告)日：2009-10-27

申请号：US10950010

申请日：2004-09-24

申请人： Dominique P. Bridon , Robert S. Dufresne , Nisssab Boudjellab , Martin Robitaille , Peter G. Milner

发明人： Dominique P. Bridon , Robert S. Dufresne , Nisssab Boudjellab , Martin Robitaille , Peter G. Milner

IPC分类号： A61K39/385 , A61K39/21

CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122

摘要： Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.

摘要翻译： 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。