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公开(公告)号：US20190151395A1
公开(公告)日：2019-05-23
申请号：US16160847
申请日：2018-10-15
发明人： Donatella Paolino , Gioacchino Folino Gallo , Massimo Fresta , Leone Spataro , Alessandro Venditti
CPC分类号： A61K36/83 , A61K8/0216 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K2236/00 , A61K2236/33 , A61Q5/006 , A61Q19/008
摘要： The invention relates to an extract obtained from Daphne laureola L to be used the pharmaceutical cosmetic and cosmeceutical field for the topical treatment of dermopathies in general and of psoriasis in particular, by means of the topical application of effective amounts of said extracts. The invention also relates to the pharmaceutical, cosmetic and cosmeceutical compositions comprising the Daphne laureola extracts. The invention also relates to the topical treatment of dermopathies in general and of psoriasis in particular.
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公开(公告)号：US20170000838A1
公开(公告)日：2017-01-05
申请号：US15100104
申请日：2014-11-26
发明人： Donatella Paolino , Gioacchino Folino Gallo , Massimo Fresta , Leone Spataro , Alessandro Venditti
CPC分类号： A61K36/83 , A61K8/0216 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K2236/00 , A61K2236/33 , A61Q5/006 , A61Q19/008
摘要： The invention relates to an extract obtained from Daphne laureola L to be used the pharmaceutical cosmetic and cosmeceutical field for the topical treatment of dermopathies in general and of psoriasis in particular, by means of the topical application of effective amounts of said extracts. The invention also relates to the pharmaceutical, cosmetic and cosmeceutical compositions comprising the Daphne laureola extracts. The invention also relates to the topical treatment of dermopathies in general and of psoriasis in particular.
摘要翻译： 本发明涉及从达芙妮（Laphne laureola L）获得的提取物，其用于通常通过局部施用有效量的所述提取物来使用用于局部治疗一般皮肤病和牛皮癣的药物化妆品和药妆领域。 本发明还涉及包含达芙妮月桂树提取物的药物，化妆品和药妆组合物。 本发明还涉及一般的皮肤病和特别是牛皮癣的局部治疗。
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公开(公告)号：US10588931B2
公开(公告)日：2020-03-17
申请号：US16160847
申请日：2018-10-15
发明人： Donatella Paolino , Gioacchino Folino Gallo , Massimo Fresta , Leone Spataro , Alessandro Venditti
IPC分类号： A61K36/00 , A61K36/83 , A61K9/00 , A61Q5/00 , A61Q19/00 , A61K8/97 , A61K9/06 , A61K9/107 , A61K8/02
摘要： The invention relates to an extract obtained from Daphne laureola L. to be used pharmaceutical cosmetic and cosmeceutical field for the topical treatment of dermopathies in general and of psoriasis in particular, by means of topical application of effective amounts of said extracts. The invention also relates to the pharmaceutical, cosmetic and cosmeceutical compositions comprising the Daphne laureola extracts. The invention also relates to the topical treatment of dermopathies in general and of psoriasis in particular.
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公开(公告)号：US10098923B2
公开(公告)日：2018-10-16
申请号：US15100104
申请日：2014-11-26
发明人： Donatella Paolino , Gioacchino Folino Gallo , Massimo Fresta , Leone Spataro , Alessandro Venditti
IPC分类号： A61K36/00 , A61K36/83 , A61K9/00 , A61Q5/00 , A61Q19/00 , A61K8/97 , A61K9/06 , A61K9/107 , A61K8/02
摘要： The invention relates to an extract obtained from Daphne laureola L to be used the pharmaceutical cosmetic and cosmeceutical field for the topical treatment of dermopathies in general and of psoriasis in particular, by means of the topical application of effective amounts of said extracts. The invention also relates to the pharmaceutical, cosmetic and cosmeceutical compositions comprising the Daphne laureola extracts. The invention also relates to the topical treatment of dermopathies in general and of psoriasis in particular.
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5.发明申请公开(公告)号：US20120288540A1
公开(公告)日：2012-11-15
申请号：US13519200
申请日：2011-01-05
CPC分类号： A61K9/0075 , A61K9/1272 , A61K9/1277 , A61K9/19
摘要： The present invention relates to a vesicular structure formed of a mixture of a non-ionic surfactant and cholesterol, characterised in that it is freeze-dried in the presence of a cryoprotectant, to a method for the preparation and to the use thereof.
摘要翻译： 本发明涉及由非离子表面活性剂和胆固醇的混合物形成的囊状结构体，其特征在于在冷冻保护剂存在下将其冷冻干燥，制备方法及其用途。
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6.发明申请Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders 审中-公开专门用于丙戊酸预防或治疗皮肤疾病公开(公告)号：US20060160897A1
公开(公告)日：2006-07-20
申请号：US11275258
申请日：2005-12-21
申请人： Pier Pelicci , Sergio Chimenti , Antonio Costanzo , Steven Nistico , Donatella Paolino , Saverio Minucci
发明人： Pier Pelicci , Sergio Chimenti , Antonio Costanzo , Steven Nistico , Donatella Paolino , Saverio Minucci
IPC分类号： A61K31/19
CPC分类号： A61K31/20 , A61K31/19 , A61K31/4436 , A61K31/505 , A61K2300/00
摘要： The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre-malignant lesions, and of inflammations of the skin and/or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.
摘要翻译： 本发明涉及含有丙戊酸或其衍生物的局部应用制剂，其可以单独使用或与局部应用的类视黄醇或核受体配体的制剂或化学治疗剂（例如5-氟尿嘧啶）组合使用。 该制剂可用于局部治疗癌性皮肤病，例如基底细胞癌，鳞状细胞癌，角化细胞瘤，鲍氏病，皮肤T细胞淋巴瘤，以及用于局部治疗恶性前病变，以及 皮肤和/或粘膜。 本发明还涉及这种局部适用的制剂用于防止紫外线和用于治疗太阳灼伤的用途。 本发明包括使用VPA制造用于局部治疗上述人类疾病的临床用药物。
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