公开(公告)号：US20180086709A1

公开(公告)日：2018-03-29

申请号：US15718474

申请日：2017-09-28

申请人： Dong-A St Co., Ltd.

发明人： Sun-Ho Choi ,  Weon-Bin Im ,  Sung-Hak Choi ,  Chong-Hwan Cho ,  Ho-Sang Moon ,  Jung-Sang Park ,  Min-Jung Lee ,  Hyun-Jung Sung ,  Jun-Hwan Moon ,  Seung-Hyun Song ,  Hyung-Keun Lee ,  Ji-Hoon Choi ,  Cheon-Hyoung Park ,  Yoon-Jung Kim ,  Jin-Hyuk Kim

IPC分类号： C07D211/70 ,  C07D401/10 ,  C07D409/10 ,  C07D405/10 ,  C07D401/04

CPC分类号： C07D211/70 ,  C07D401/04 ,  C07D401/10 ,  C07D405/10 ,  C07D409/10

摘要： The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.

公开(公告)号：US10160724B2

公开(公告)日：2018-12-25

申请号：US15718474

申请日：2017-09-28

申请人： Dong-A St Co., Ltd.

发明人： Sun-Ho Choi ,  Weon-Bin Im ,  Sung-Hak Choi ,  Chong-Hwan Cho ,  Ho-Sang Moon ,  Jung-Sang Park ,  Min-Jung Lee ,  Hyun-Jung Sung ,  Jun-Hwan Moon ,  Seung-Hyun Song ,  Hyung-Keun Lee ,  Ji-Hoon Choi ,  Cheon-Hyoung Park ,  Yoon-Jung Kim ,  Jin-Hyuk Kim

IPC分类号： C07D211/70 ,  C07D401/04 ,  C07D401/10 ,  C07D405/10 ,  C07D409/10

摘要： The present disclosure relates to a novel tetrahydropyridine derivative compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, methods for preparing the compounds, methods for inhibiting UDP-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), methods for treating Gram-negative bacterial infections, the use of the compounds for the preparation of therapeutic medicaments for treating Gram-negative bacterial infections, and pharmaceutical compositions for prevention or treatment of Gram-negative bacterial infections, which contain the compounds. The compounds represented by formula I, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present disclosure can exhibit excellent effects on the treatment bacterial infections.