公开(公告)号：US20050044122A1

公开(公告)日：2005-02-24

申请号：US10771407

申请日：2004-02-05

申请人： Dong-Soo Han ,  Hong-Soog Kim ,  Jung-Min Seo ,  Woo-Hyuk Jang

发明人： Dong-Soo Han ,  Hong-Soog Kim ,  Jung-Min Seo ,  Woo-Hyuk Jang

IPC分类号： G01N33/48 ,  G06F17/15 ,  G06F19/00 ,  G06F19/18 ,  G06F19/22

CPC分类号： G16B5/00 ,  G16B20/00

摘要： Disclosed are a system and a method for statistically predicting an interaction probability between proteins, and more particularly to a system and a method for predicting an interaction probability between an unknown protein pair based on information obtained by analyzing differences between interacting and non-interacting sets of protein pairs from the view point of domain combination. The prediction method includes the steps of (a) obtaining appearance frequency information of a designated domain combination selected from each of interacting and non-interacting sets of protein pairs, and storing the obtained appearance frequency information, (b) determining a probability equation applied to predict the interaction between two proteins using the stored appearance frequency information of the domain combination, and (c) obtaining an interaction probability value between the two proteins from the determined probability equation.

摘要翻译： 公开了用于统计预测蛋白质之间的相互作用概率的系统和方法，更具体地涉及一种系统和方法，用于基于通过分析相互作用和非相互作用的组之间的差异而获得的信息来预测未知蛋白质对之间的相互作用概率 从组合角度看蛋白质对。 该预测方法包括以下步骤：（a）从蛋白质对的相互作用和非相互作用的集合中选出的指定结构域组合的出现频度信息，存储所获得的出现频度信息，（b）确定应用于 使用所述域组合的存储的出现频率信息预测两种蛋白质之间的相互作用，以及（c）从确定的概率方程式获得两种蛋白质之间的相互作用概率值。