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    METHODS AND SYSTEMS FOR DESIGNING STABLE PROTEINS
    2.
    发明申请
    METHODS AND SYSTEMS FOR DESIGNING STABLE PROTEINS 审中-公开
    用于设计稳定蛋白质的方法和系统

    公开(公告)号：US20120265513A1

    公开(公告)日：2012-10-18

    申请号：US13442611

    申请日：2012-04-09

    申请人： Jianwen Fang ,  Yunqi Li ,  C. Russell Middaugh

    发明人： Jianwen Fang ,  Yunqi Li ,  C. Russell Middaugh

    IPC分类号： G06F19/12

    CPC分类号： G16B20/00 ,  G16B15/00

    摘要： Methods and computing systems for generating a protein stability lookup table and a predictive model. These methods and systems are useful for predicting the thermal stability of a protein sequence and for predicting mutations that may enhance the thermal stability of a protein given its amino acid sequence and/or three dimensional structure. The protein stability lookup table and a predictive model are based on a combination and analysis of related protein sequences and, where available, protein structure data, and relative stability data from mesophilic and thermophilic organisms and experimentally determined stability changes of wild type proteins and their mutants.

    摘要翻译： 用于产生蛋白质稳定性查询表和预测模型的方法和计算系统。 这些方法和系统可用于预测蛋白质序列的热稳定性和用于预测鉴定其氨基酸序列和/或三维结构的蛋白质的热稳定性的突变。 蛋白质稳定性查询表和预测模型基于相关蛋白质序列的组合和分析，以及可用的蛋白质结构数据和嗜温嗜热生物体的相对稳定性数据以及实验确定的野生型蛋白及其突变体的稳定性变化 。

    Stabilizers for fibroblast growth factors
    3.
    发明授权
    Stabilizers for fibroblast growth factors 失效
    成纤维细胞生长因子稳定剂

    公开(公告)号：US5348941A

    公开(公告)日：1994-09-20

    申请号：US861060

    申请日：1992-04-01

    申请人： C. Russell Middaugh ,  Pei-Kuo Tsai ,  David B. Volkin

    发明人： C. Russell Middaugh ,  Pei-Kuo Tsai ,  David B. Volkin

    IPC分类号： A61K38/18 ,  A61K47/02 ,  A61K47/24 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K37/02 ,  A61K37/36

    CPC分类号： A61K38/1825 ,  A61K47/02 ,  A61K47/24 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40 ,  A61K9/0014 ,  Y10S514/97

    摘要： Medicinal compositions containing fibroblast growth factor are stabilized against loss of biological activity by including in said composition a stabilizing amount of phytic add, phosvitin, phosphate buffer, (NH.sub.4).sub.6 P.sub.4 O.sub.13, Na.sub.5 P.sub.3 O.sub.10, Na.sub.4 P.sub.2 O.sub.7 and Na.sub.3 P.sub.3 O.sub.9, adenosine tetra, tri, di and mono phosphate and related diadenosine compounds plus other single and multi-phosphorylated mono and di-nucleotides, poly-aspartic acid, poly-adenylic-guanylic add and related compounds, double stranded deoxyribonucleic add, single stranded deoxyfibonucleic acid and poly-glutamic acid. Medicinal compositions for topical use are combined with a viscous excipient such as a water soluble polysaccharide with said combination with a second stabilizier.

    摘要翻译： 含有成纤维细胞生长因子的药物组合物通过在所述组合物中包含稳定量的植酸添加物，卵磷脂，磷酸盐缓冲液，（NH 4）6 P 4 O 13，Na 5 P 3 O 10，Na 4 P 2 O 7和Na 3 P 3 O 9，腺苷四，三，二和单 磷酸盐和相关的二腺苷化合物加上其他单和多磷酸化单和二核苷酸，聚天冬氨酸，聚腺苷酸 - 鸟苷酸加成和相关化合物，双链脱氧核糖核酸，单链脱氧纤维核糖酸和聚谷氨酸。 用于局部使用的药物组合物与粘性赋形剂如水溶性多糖组合，所述组合与第二稳定剂组合。