-
公开(公告)号：US08227439B2
公开(公告)日：2012-07-24
申请号：US12466599
申请日：2009-05-15
申请人： Alison O'Neill , Douglas B. Jacoby , Abdellah Sentissi , Kamala Kesavan , E. Michael Egan , Laura Sen, legal representative
CPC分类号： A61K51/08 , A61K38/164 , A61K38/1767 , A61K45/06 , A61K47/60 , A61K47/6415 , C07K2319/33 , C07K2319/55 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/31 , C12N2320/32
摘要： The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
摘要翻译： 本发明涉及用于治疗，抑制和/或减少和检测转移性肿瘤的方法和方法。 在一些实施方案中，本发明的方法包括全身（例如静脉内）施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗，抑制和/或减少和检测脑中的转移。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。
-
公开(公告)号：US08470607B2
公开(公告)日：2013-06-25
申请号：US12933638
申请日：2008-09-17
IPC分类号： G01N33/566 , G01N33/53 , C12N5/00 , C07K14/00
CPC分类号： A61K38/1767 , A61K9/0048 , A61K47/36 , A61K47/38 , G01N33/574 , G01N2333/43521 , G01N2800/7014
摘要： The present invention is directed to novel methods of inhibiting angiogenesis using chlorotoxin agents. In some embodiments, the inventive methods include intravenous, intraocular, intravitreal, subjunctival injection, and/or topical administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment and/or amelioration of ocular diseases characterized by neovascularization, such as wet macular degeneration. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
摘要翻译： 本发明涉及使用氯毒素试剂抑制血管发生的新方法。 在一些实施方案中，本发明的方法包括静脉内，眼内，玻璃体内，结膜下注射和/或局部施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗和/或改善以新血管形成为特征的眼部疾病，例如湿性黄斑变性。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。
-
公开(公告)号：US20090304592A1
公开(公告)日：2009-12-10
申请号：US12466599
申请日：2009-05-15
申请人： Alison O'Neill , Douglas B. Jacoby , Abdellah Sentissi , Kamala Kesavan , E. Michael Egan , Laura Sen
发明人： Alison O'Neill , Douglas B. Jacoby , Abdellah Sentissi , Kamala Kesavan , E. Michael Egan , Laura Sen
CPC分类号： A61K51/08 , A61K38/164 , A61K38/1767 , A61K45/06 , A61K47/60 , A61K47/6415 , C07K2319/33 , C07K2319/55 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/31 , C12N2320/32
摘要： The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
摘要翻译： 本发明涉及用于治疗，抑制和/或减少和检测转移性肿瘤的方法和方法。 在一些实施方案中，本发明的方法包括全身（例如静脉内）施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗，抑制和/或减少和检测脑中的转移。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。
-
公开(公告)号：US20110027177A1
公开(公告)日：2011-02-03
申请号：US12933638
申请日：2008-09-17
IPC分类号： A61K51/08 , A61P35/00 , A61P35/02 , A61K38/17 , A61K39/395 , A61P27/02 , A61P27/10 , A61K38/54 , G01N33/53 , C12N5/00
CPC分类号： A61K38/1767 , A61K9/0048 , A61K47/36 , A61K47/38 , G01N33/574 , G01N2333/43521 , G01N2800/7014
摘要： The present invention is directed to novel methods of inhibiting angiogenesis using chlorotoxin agents. In some embodiments, the inventive methods include intravenous, intraocular, intravitreal, subjunctival injection, and/or topical administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment and/or amelioration of ocular diseases characterized by neovascularization, such as wet macular degeneration. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
摘要翻译： 本发明涉及使用氯毒素试剂抑制血管发生的新方法。 在一些实施方案中，本发明的方法包括静脉内，眼内，玻璃体内，结膜下注射和/或局部施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗和/或改善以新血管形成为特征的眼部疾病，例如湿性黄斑变性。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。
-
公开(公告)号：US20130045163A1
公开(公告)日：2013-02-21
申请号：US13479203
申请日：2012-05-23
CPC分类号： A61K51/08 , A61K38/164 , A61K38/1767 , A61K45/06 , A61K47/60 , A61K47/6415 , C07K2319/33 , C07K2319/55 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/31 , C12N2320/32
摘要： The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
-
公开(公告)号：US09023595B2
公开(公告)日：2015-05-05
申请号：US13479203
申请日：2012-05-23
CPC分类号： A61K51/08 , A61K38/164 , A61K38/1767 , A61K45/06 , A61K47/60 , A61K47/6415 , C07K2319/33 , C07K2319/55 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2320/31 , C12N2320/32
摘要： The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
摘要翻译： 本发明涉及用于治疗，抑制和/或减少和检测转移性肿瘤的方法和方法。 在一些实施方案中，本发明的方法包括全身（例如静脉内）施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗，抑制和/或减少和检测脑中的转移。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。
-
公开(公告)号：US20110091380A1
公开(公告)日：2011-04-21
申请号：US12672069
申请日：2008-08-07
IPC分类号： A61K51/08 , C07K14/435 , C12N9/96 , A61K38/17 , A61P35/00 , A61K38/43 , A61K31/7105 , A61K39/385
CPC分类号： A61K47/6415
摘要： The present invention relates to the use of a toxin moiety (e.g., a chlorotoxin moiety) as a carrier for therapeutic agents, e.g., therapeutic agents that require intracellular uptake to exert their effects. For example, in some embodiments, the present invention provides conjugates comprising a toxin (e.g., a chlorotoxin) moiety and an anti-cancer moiety and methods for using such conjugates to increase cellular uptake and/or increase specificity for cancer cells of the anti-cancer drug. In some embodiments, the present invention provides conjugates comprising a toxin moiety (e.g., a chlorotoxin moiety) and a nucleic acid agent. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.
摘要翻译： 本发明涉及毒素部分（例如，氯毒素部分）作为治疗剂的载体的用途，例如需要细胞内吸收发挥其作用的治疗剂。 例如，在一些实施方案中，本发明提供了包含毒素（例如，氯毒素）部分和抗癌部分的缀合物以及使用这种缀合物增加细胞摄取和/或增加抗 - 癌症药物。 在一些实施方案中，本发明提供了包含毒素部分（例如，氯毒素部分）和核酸试剂的缀合物。 还提供了涉及施用这种缀合物的治疗方法，以及可用于实施这些治疗方法的药物组合物和试剂盒。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.025 秒)
