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11 条记录 (耗时 0.03 秒)

    Inhibition of angiogenesis
    3.
    发明授权
    Inhibition of angiogenesis 有权
    抑制血管发生

    公开(公告)号：US08470607B2

    公开(公告)日：2013-06-25

    申请号：US12933638

    申请日：2008-09-17

    申请人： Douglas B. Jacoby ,  Abdellah Sentissi ,  E. Michael Egan ,  Kamala Kesavan

    发明人： Douglas B. Jacoby ,  Abdellah Sentissi ,  E. Michael Egan ,  Kamala Kesavan

    IPC分类号： G01N33/566 ,  G01N33/53 ,  C12N5/00 ,  C07K14/00

    CPC分类号： A61K38/1767 ,  A61K9/0048 ,  A61K47/36 ,  A61K47/38 ,  G01N33/574 ,  G01N2333/43521 ,  G01N2800/7014

    摘要： The present invention is directed to novel methods of inhibiting angiogenesis using chlorotoxin agents. In some embodiments, the inventive methods include intravenous, intraocular, intravitreal, subjunctival injection, and/or topical administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment and/or amelioration of ocular diseases characterized by neovascularization, such as wet macular degeneration. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.

    摘要翻译： 本发明涉及使用氯毒素试剂抑制血管发生的新方法。 在一些实施方案中，本发明的方法包括静脉内，眼内，玻璃体内，结膜下注射和/或局部施用可能标记或可能不标记的氯毒素试剂。 在一些实施方案中，本发明的方法允许治疗和/或改善以新血管形成为特征的眼部疾病，例如湿性黄斑变性。 在一些实施方案中，新血管形成被抑制并且/或新形成的血管被引起退化。

    CHLOROTOXINS AS DRUG CARRIERS
    9.
    发明申请
    CHLOROTOXINS AS DRUG CARRIERS 审中-公开
    氯霉素作为药物载体

    公开(公告)号：US20110091380A1

    公开(公告)日：2011-04-21

    申请号：US12672069

    申请日：2008-08-07

    申请人： Douglas Jacoby ,  Abdellah Sentissi ,  E. Michael Egan

    发明人： Douglas Jacoby ,  Abdellah Sentissi ,  E. Michael Egan

    IPC分类号： A61K51/08 ,  C07K14/435 ,  C12N9/96 ,  A61K38/17 ,  A61P35/00 ,  A61K38/43 ,  A61K31/7105 ,  A61K39/385

    CPC分类号： A61K47/6415

    摘要： The present invention relates to the use of a toxin moiety (e.g., a chlorotoxin moiety) as a carrier for therapeutic agents, e.g., therapeutic agents that require intracellular uptake to exert their effects. For example, in some embodiments, the present invention provides conjugates comprising a toxin (e.g., a chlorotoxin) moiety and an anti-cancer moiety and methods for using such conjugates to increase cellular uptake and/or increase specificity for cancer cells of the anti-cancer drug. In some embodiments, the present invention provides conjugates comprising a toxin moiety (e.g., a chlorotoxin moiety) and a nucleic acid agent. Also provided are methods of treatment involving administration of such conjugates, and pharmaceutical compositions and kits useful for carrying out such methods of treatment.

    摘要翻译： 本发明涉及毒素部分（例如，氯毒素部分）作为治疗剂的载体的用途，例如需要细胞内吸收发挥其作用的治疗剂。 例如，在一些实施方案中，本发明提供了包含毒素（例如，氯毒素）部分和抗癌部分的缀合物以及使用这种缀合物增加细胞摄取和/或增加抗 - 癌症药物。 在一些实施方案中，本发明提供了包含毒素部分（例如，氯毒素部分）和核酸试剂的缀合物。 还提供了涉及施用这种缀合物的治疗方法，以及可用于实施这些治疗方法的药物组合物和试剂盒。

    Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin
    10.
    发明授权
    Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin 失效
    重复的打击和运行免疫测定和稳定的支持 - 分析物缀合物; 适用于T-2毒素

    公开(公告)号：US4801726A

    公开(公告)日：1989-01-31

    申请号：US852144

    申请日：1986-04-15

    申请人： Roger W. Giese ,  Beverly Warden ,  Allam Kariman ,  Markus Ehrat ,  Douglas J. Cecchini ,  Abdellah Sentissi

    发明人： Roger W. Giese ,  Beverly Warden ,  Allam Kariman ,  Markus Ehrat ,  Douglas J. Cecchini ,  Abdellah Sentissi

    IPC分类号： G01N33/543 ,  G01N33/552 ,  G01N33/569 ,  C07F7/10

    CPC分类号： G01N33/54306 ,  G01N33/54353 ,  G01N33/552 ,  G01N33/56911

    摘要： A repetitive immunoassay analytical method for determination of a free analyte is carried out by loading an affinity column of covalently bound analyte with tagged antibody, passing a continuous aqueous stream of carrier liquid over the column, introducing an aliquot of a sample to be analyzed for free analyte into the carrier stream upstream of the column, and monitoring the eluting carrier stream for a signal spike resulting from the presence of tagged antibody material released from the column by the application of free analyte in the analytical sample. Many samples may be analyzed by this method before the antibody-loaded affinity column needs to be regenerated. It is also disclosed that substrate-analyte conjugates of superior stability are produced by linking a substrate to a hydroxyalkyl analyte via an amino, hydrazide, or sulfide linking group replacing a hydroxy group. Such stable substrate-analyte conjugates are useful in the production and purification of antibodies, as well as in the repetitive immunoassay of the invention.

    摘要翻译： 用于测定游离分析物的重复免疫测定分析方法是通过将带有标记抗体的共价结合分析物的亲和柱加载，将载体液体的连续含水流通过柱，将待分析样品的等分试样释放 将分析物分析到柱上游的载体流中，并且通过在分析样品中施用游离分析物，监测从洗脱塔释放的标记的抗体材料的存在引起的信号尖峰的洗脱载体流。 在需要再生抗体加载的亲和柱之前，可以通过该方法分析许多样品。 还公开了通过经由取代羟基的氨基，酰肼或硫化物连接基团将底物与羟烷基分析物连接而产生优异稳定性的底物分析物缀合物。 这种稳定的底物分析物缀合物可用于抗体的生产和纯化，以及本发明的重复免疫测定。