公开(公告)号：US20140328804A1

公开(公告)日：2014-11-06

申请号：US14124800

申请日：2012-06-11

申请人： Douglas G. McFadden ,  Eric C. Bartee ,  Christopher R. Cogle

发明人： Douglas G. McFadden ,  Eric C. Bartee ,  Christopher R. Cogle

IPC分类号： A61K35/28

CPC分类号： A61K35/28 ,  A61K35/14 ,  A61K35/17 ,  A61K35/768 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0636 ,  C12N2710/24041

摘要： A method of treating or preventing graft versus host disease (GVHD) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a Myxoma Virus effective to inhibit proliferation of T lymphocytes in the graft and to treat or prevent GVHD in the host subject following infusion of the graft into the subject. After the contacting of the graft with the Myxoma Virus, the method comprises transplanting the virus-treated graft into the subject.

摘要翻译： 提供了在接受包含造血细胞的移植物的受试者中治疗或预防移植物抗宿主病（GVHD）的方法。 该方法包括将移植物离体接触一定量的有效抑制移植物中T淋巴细胞增殖的粘液瘤病毒，并在将移植物输注入受试者之后治疗或预防宿主受试者中的GVHD。 在移植物与粘液瘤病毒接触之后，该方法包括将病毒处理的移植物移植到受试者中。

公开(公告)号：US09730960B2

公开(公告)日：2017-08-15

申请号：US14124800

申请日：2012-06-11

申请人： Douglas G. McFadden ,  Eric C. Bartee ,  Christopher R. Cogle

发明人： Douglas G. McFadden ,  Eric C. Bartee ,  Christopher R. Cogle

IPC分类号： A61K35/28 ,  A61K35/768 ,  A61K35/17 ,  A61K35/14 ,  C12N5/0783 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61K35/14 ,  A61K35/17 ,  A61K35/768 ,  A61K2035/122 ,  A61K2035/124 ,  C12N5/0636 ,  C12N2710/24041

摘要： A method of treating or preventing graft versus host disease (GVHD) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a Myxoma Virus effective to inhibit proliferation of T lymphocytes in the graft and to treat or prevent GVHD in the host subject following infusion of the graft into the subject. After the contacting of the graft with the Myxoma Virus, the method comprises transplanting the virus-treated graft into the subject.