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11 条记录 (耗时 0.022 秒)

    Compositions of Allosteric Hemoglobin Modifiers and Methods of Making the Same
    2.
    发明申请
    Compositions of Allosteric Hemoglobin Modifiers and Methods of Making the Same 审中-公开
    变构血红蛋白改性剂的组成及其制备方法

    公开(公告)号：US20070293698A1

    公开(公告)日：2007-12-20

    申请号：US10598874

    申请日：2005-04-22

    申请人： Al Quick ,  Antonio Santos ,  Alexandre J.G. Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Chris Murray

    发明人： Al Quick ,  Antonio Santos ,  Alexandre J.G. Carvalho ,  Douglas Johnson ,  Jeffrey Etter ,  Chris Murray

    IPC分类号： C07C233/01 ,  C07C231/00 ,  G01N30/00 ,  C07C233/00

    CPC分类号： A61K31/195

    摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.

    摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。

    DISPLAYING A PLURALITY OF SELECTABLE ACTIONS
    10.
    发明申请
    DISPLAYING A PLURALITY OF SELECTABLE ACTIONS 审中-公开
    显示多种可选择的行动

    公开(公告)号：US20150293667A1

    公开(公告)日：2015-10-15

    申请号：US14252223

    申请日：2014-04-14

    申请人： Mark Joseph Eppolito ,  Shawn Piper ,  Brandon Fasching ,  Jessica Tobar ,  Chris Murray

    发明人： Mark Joseph Eppolito ,  Shawn Piper ,  Brandon Fasching ,  Jessica Tobar ,  Chris Murray

    IPC分类号： G06F3/0481 ,  G06F3/0488

    CPC分类号： G06F3/0488 ,  G06F3/0482

    摘要： An item page may be displayed on a client device in response to a request to view an item page from the client device. They item page may include a description of the item. An icon may be generated and the icon may be displayed within a portion of the displayed item page at an icon location. A plurality of selectable actions each being performable with respect to the item described by the item page may be generated and displayed in response to an initial gesture being performed at the icon location for at least a pre-defined threshold duration. Lastly, the plurality of selectable actions may be displayed around the generated icon and within a pre-defined distance from the icon location of the generated icon.

    摘要翻译： 响应于从客户端设备查看项目页面的请求，可以在客户端设备上显示项目页面。 它们的项目页面可以包括项目的描述。 可以生成图标，并且图标可以在图标位置处显示在所显示的项目页面的一部分内。 响应于在图标位置处执行至少预定义的阈值持续时间的初始手势，可以生成并显示关于由项目页描述的项目执行的多个可选择动作。 最后，可以围绕生成的图标显示多个可选动作，并且在与所生成的图标的图标位置之间的预定距离内显示。