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    CATHETER WITH ULTRASOUND TRANSDUCER AND VARIABLE FOCUS LENS USED IN ANEURYSM ASSESSMENT
    1.
    发明申请
    CATHETER WITH ULTRASOUND TRANSDUCER AND VARIABLE FOCUS LENS USED IN ANEURYSM ASSESSMENT 审中-公开
    超声波传感器和可变焦度镜头用于防护评估的导管

    公开(公告)号：US20100076317A1

    公开(公告)日：2010-03-25

    申请号：US12516617

    申请日：2007-11-16

    申请人： Drazenko Babic ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks

    发明人： Drazenko Babic ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks

    IPC分类号： A61B8/14

    CPC分类号： A61B8/12 ,  A61B5/02014 ,  A61B8/06 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/483 ,  A61B17/12113 ,  A61B17/1214 ,  A61B2017/1205 ,  G10K11/30

    摘要： A catheter having ultrasound capability and a distal end extending along a longitudinal axis, the end being situated adjacent to a tissue of interest inside of a patient; at least one ultrasound transducer located in the end to direct ultrasound waves along the axis in a generally forward direction relative to the end; a variable-focus lens system located in the end, downstream of the transducer in the generally forward direction, the lens system being capable of variably focusing the ultrasound waves emitted by the transducer at various positions downstream of the lens and catheter end; optionally, a mirror located in the end, downstream of the transducer and the lens system in the generally forward direction, whereby the emitted ultrasound waves from the lens system are either reflected from the mirror and focused at a position substantially perpendicular to the longitudinal axis; or the emitted ultrasound waves from the lens system substantially bypass the mirror in unreflected form and are focused at a position downstream of the transducer, the lens system and the mirror in the generally forward direction along the longitudinal axis; and imaging means for translating the focused ultrasound waves from the lens system reflected and/or unreflected by the mirror into three-dimensional images and communicating the images in viewable form to a human operator that is external to the patient. A method of measuring, imaging and viewing blood flow velocity and patterns in a blood vessel and aneurysm, as well as monitoring vaso-occlusive coil placement in an aneurysm during a surgical intervention using the catheter, is also disclosed.

    摘要翻译： 具有超声波能力的导管和沿着纵向轴线延伸的远端，所述端部位于与患者体内的感兴趣组织相邻的位置; 位于所述端部的至少一个超声波换能器沿着所述轴线在相对于所述端部的大致向前方向上引导超声波; 可变焦距透镜系统位于传感器的大致向前方的下游，透镜系统能够在透镜和导管端的下游的各个位置处可变地聚焦由换能器发射的超声波; 可选地，位于换能器下游的镜子和大致正向的透镜系统，由此来自透镜系统的发射的超声波或者从反射镜反射并且在基本上垂直于纵向轴线的位置聚焦; 或者来自透镜系统的发射的超声波基本上以未反射的形式旁路反射镜，并且沿着纵轴在大致向前的方向上聚焦在换能器，透镜系统和反射镜的下游位置处; 以及成像装置，用于将由镜子反射和/或未反射的透镜系统的聚焦超声波转换为三维图像，并将可视形式的图像传送给患者外部的人类操作者。 还公开了一种在使用导管的外科手术中测量，成像和观察血管和动脉瘤中的血流速度和图案的方法以及监测动脉瘤中的血管闭塞线圈放置。

    Methods and apparatuses of microbeamforming with adjustable fluid lenses
    4.
    发明授权
    Methods and apparatuses of microbeamforming with adjustable fluid lenses 失效
    具有可调节流体透镜的微波成像的方法和装置

    公开(公告)号：US08764665B2

    公开(公告)日：2014-07-01

    申请号：US12596841

    申请日：2008-04-30

    申请人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    发明人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    IPC分类号： A61B8/00

    CPC分类号： G10K11/30

    摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

    摘要翻译： 声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。 每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。 在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

    System for variably refracting ultrasound and/or light
    5.
    发明授权
    System for variably refracting ultrasound and/or light 失效
    用于可变地折射超声和/或光的系统

    公开(公告)号：US08422338B2

    公开(公告)日：2013-04-16

    申请号：US12376307

    申请日：2007-04-12

    申请人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Jan Frederik Suijver

    发明人： Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Jan Frederik Suijver

    IPC分类号： G10K11/30

    CPC分类号： G10K11/30

    摘要： The disclosure is directed to a system for variably refracting, and is transparent for, ultrasound as well as for light. By choosing liquids with the right optical and acoustical properties, it is possible to variably refract (including focusing and deflecting or steering) ultrasound while not affecting the refraction of light, or vice versa. Two lenses in series, or preferably one lens, allow for variably refracting ultrasound and light.

    摘要翻译： 本公开涉及用于可变折射并且对于超声波以及用于光的透明系统。 通过选择具有正确光学和声学特性的液体，可以可变地折射（包括聚焦和偏转或转向）超声波，同时不影响光的折射，反之亦然。 串联的两个镜片，或者优选地，一个透镜允许可变地折射超声波和光。

    Hydrogel based sensor probe for detecting an environmental state
    6.
    发明授权
    Hydrogel based sensor probe for detecting an environmental state 失效
    用于检测环境状态的基于水凝胶的传感器探头

    公开(公告)号：US08244078B2

    公开(公告)日：2012-08-14

    申请号：US12600881

    申请日：2008-05-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    IPC分类号： G02B6/00

    CPC分类号： G01N21/7703 ,  A61B5/0084 ,  A61B5/14539 ,  G01N2021/772 ,  G01N2021/7723 ,  G01N2021/773 ,  G01N2021/7779

    摘要： A sensor probe for detecting an environmental state within a bodily lumen includes an elongated body having an optical guide with an outcoupling surface, which is part of an end surface of the elongated body, facing a reflective surface of an overhanging part. The sensor probe further includes a photodetector which detects a property of light which is composed of light in the optical guide that is reflected from the outcoupling surface of the optical guide and of light in the optical guide that is reflected from the overhanging part. The sensor probe also includes a hydrogel material having a property that changes when getting into contact with an environmental material and/or when detecting an environmental change. The hydrogel material is provided between the end surface of the elongated body and the overhanging part.

    摘要翻译： 用于检测身体腔内的环境状态的传感器探针包括细长体，其具有带有外耦合表面的光导，所述光耦合器是细长体的端表面的一部分，面向突出部分的反射表面。 传感器探头还包括光电检测器，其检测由光导中的光构成的光的特性，所述光从光导的输出耦合表面反射，以及从突出部反射的光导中的光。 传感器探头还包括具有在与环境材料接触和/或当检测到环境变化时变化的性质的水凝胶材料。 水凝胶材料设置在细长体的端面与突出部之间。

    METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES
    7.
    发明申请
    METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 失效
    具有可调节流体镜片的微球的方法和装置

    公开(公告)号：US20100087735A1

    公开(公告)日：2010-04-08

    申请号：US12596841

    申请日：2008-04-30

    申请人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    发明人： Christopher Stephen Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    IPC分类号： A61B8/00 ,  G03B42/06

    CPC分类号： G10K11/30

    摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

    摘要翻译： 声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。 每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。 在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

    Method and apparatus for elevation focus control of acoustic waves
    8.
    发明授权
    Method and apparatus for elevation focus control of acoustic waves 有权
    用于声波高程聚焦控制的方法和装置

    公开(公告)号：US07957219B2

    公开(公告)日：2011-06-07

    申请号：US12297902

    申请日：2007-04-27

    申请人： Christopher S. Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    发明人： Christopher S. Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    IPC分类号： G03B42/06

    CPC分类号： G10K11/30

    摘要： An acoustic probe includes an acoustic transducer having acoustic transducer elements arranged in a one-dimensional array; and a variably-refracting acoustic lens coupled to the acoustic transducer. The variably-refracting acoustic lens has a pair of electrodes configured to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

    摘要翻译： 声探头包括具有以一维阵列布置的声换能器元件的声换能器; 以及耦合到声换能器的可变折射声透镜。 可变折射声透镜具有一对电极，其被配置为响应于跨过电极施加的选定电压来调节可变折射声透镜的焦点。 在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

    FLUID LENS WITH PRESSURE RELEASE SYSTEM
    9.
    发明申请
    FLUID LENS WITH PRESSURE RELEASE SYSTEM 有权
    带压力释放系统的流体镜

    公开(公告)号：US20100277809A1

    公开(公告)日：2010-11-04

    申请号：US12811831

    申请日：2009-01-12

    申请人： Jan Frederik Suijver ,  Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Antonius Johannes Josephus Rademakers ,  Cornelius Antonius Micolaas Maria Van Der Vleuten ,  Johannes Wilhelmus Weekamp ,  Waltherus Cornelis Jozef Bierhoff

    发明人： Jan Frederik Suijver ,  Stein Kuiper ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Antonius Johannes Josephus Rademakers ,  Cornelius Antonius Micolaas Maria Van Der Vleuten ,  Johannes Wilhelmus Weekamp ,  Waltherus Cornelis Jozef Bierhoff

    IPC分类号： G02B3/14 ,  A61B1/06

    CPC分类号： G02B7/008 ,  A61B1/0019 ,  G02B3/14 ,  G02B23/2407

    摘要： Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.

    摘要翻译： 流体透镜系统，例如 用于医疗成像或医疗处理，容器包围布置成折射入射波的流体。 压力释放机构与流体接触，以便补偿由于热变化引起的体积变化，例如， 在高温医疗清洗过程中。 该压力释放机构位于入射波的通路内。 在优选实施例中，经由管连接到作为储存器的流体的流体容器设置在容器内或外部，例如， 超越图像传感器。 或者，容易压缩的主体，例如， 围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。 在两个实施例中，压力释放元件优选地定位在入射波通路的周边部分中，从而不影响透镜的性能。 在另一方面，一种流体透镜包括具有内部容器部分的容器，该内部容器部分装配在外部容器部分内部，其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。 压力释放机构定位在外部容器部分内，并且与流体接触，以补偿由于热变化引起的流体体积的变化。 在一个实施例中，内部和外部容器部件布置用于相对一维运动并且流体密封互连。 在另一个实施例中，在内部和外部容器部分之间形成流体填充空腔，并且该空腔容纳可压缩体。 透镜系统适用于诸如医用内窥镜，导管和针的应用，光学和声学基础。