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    ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS
    2.
    发明申请
    ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 失效
    可调镜头系统实时应用

    公开(公告)号：US20100259832A1

    公开(公告)日：2010-10-14

    申请号：US12742658

    申请日：2008-12-10

    申请人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    发明人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    IPC分类号： G02B3/14

    CPC分类号： G02B3/14

    摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

    摘要翻译： 提供了一种可调节流体型透镜系统， 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器，例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用，例如， 在医疗领域内。 用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

    DEVICE CONTAINING A FLUID REFRACTING ULTRASOUND MODALITY
    3.
    发明申请
    DEVICE CONTAINING A FLUID REFRACTING ULTRASOUND MODALITY 审中-公开
    含有流体超薄超声波模型的装置

    公开(公告)号：US20100229648A1

    公开(公告)日：2010-09-16

    申请号：US12438170

    申请日：2007-04-12

    申请人： Jan Frederik Suijver ,  Anna T. Fernandez ,  Christopher S. Hall

    发明人： Jan Frederik Suijver ,  Anna T. Fernandez ,  Christopher S. Hall

    IPC分类号： G01N29/02

    CPC分类号： G10K11/30

    摘要： An acoustic device is disclosed having a variably refracting acoustic fluid interface including the boundary between two separate fluid media, means for directing acoustic waves onto the interface, and an acoustic generator or transducer located in one of the fluid media with the acoustic generator having an impedance that is substantially equal to the one said fluid media to minimize signal loss and reflection.

    摘要翻译： 公开了一种声学装置，其具有包括两个单独流体介质之间的边界的可变折射声流体界面，用于将声波引导到界面上的装置，以及位于一个流体介质中的声发生器或换能器，声发生器具有阻抗 其基本上等于所述流体介质以最小化信号损失和反射。

    LIGHT-EMITTING APPARATUS, PARTICULARLY FOR FLOW MEASUREMENTS
    5.
    发明申请
    LIGHT-EMITTING APPARATUS, PARTICULARLY FOR FLOW MEASUREMENTS 审中-公开
    发光装置，特别用于流量测量

    公开(公告)号：US20100185106A1

    公开(公告)日：2010-07-22

    申请号：US12376630

    申请日：2007-08-06

    申请人： Jan Frederik Suijver ,  Mischa Megens ,  Drazenko Babic

    发明人： Jan Frederik Suijver ,  Mischa Megens ,  Drazenko Babic

    IPC分类号： A61B5/02

    CPC分类号： G01S17/58 ,  A61B5/027 ,  G01S7/4811 ,  G02B6/2726 ,  G02B6/2773

    摘要： The invention relates to a light-emitting apparatus (100) comprising an optical waveguide, particularly an optical fiber (1), for guiding a primary light beam (Bprim) into a light-splitting unit (101) which splits it into two or more partial light beams (B1, B3, B4) which are emitted in different directions and have different optical qualities, e.g. different spectral compositions or polarizations. The apparatus may optionally comprise a detector (4) for determining a Doppler shift (Δλi) in reflected light reentering the light-splitting unit (101). This renders it possible to measure simultaneously two or more spatially independent vector components of the flow velocity of a fluid, particularly of blood, surrounding the light-splitting unit (101).

    摘要翻译： 本发明涉及一种发光装置（100），其包括用于将初级光束（Bprim）引导到光分离单元（101）中的光波导，特别是光纤（1），其将其分成两个或更多个 在不同方向发射并具有不同光学质量的部分光束（B1，B3，B4），例如， 不同的光谱组成或极化。 该装置可以可选地包括用于确定重新进入光分离单元（101）的反射光中的多普勒频移（＆Dgr;λi）的检测器（4）。 这使得可以同时测量围绕光分离单元（101）的流体（特别是血液）的流速的两个或更多个空间上独立的矢量分量。

    Vacuum cleaning device
    6.
    发明授权
    Vacuum cleaning device 有权
    真空清洗装置

    公开(公告)号：US09259128B2

    公开(公告)日：2016-02-16

    申请号：US14008010

    申请日：2012-04-05

    申请人： Jan Frederik Suijver ,  Gerben Kooijman ,  Okke Ouweltjes ,  Jeroen Herman Lammers ,  Rene Henk Van Der Woude

    发明人： Jan Frederik Suijver ,  Gerben Kooijman ,  Okke Ouweltjes ,  Jeroen Herman Lammers ,  Rene Henk Van Der Woude

    IPC分类号： A47L5/00 ,  A47L9/04

    CPC分类号： A47L9/0483 ,  A47L9/0461

    摘要： A vacuum cleaning device comprises a unit (1) for aerodynamically affecting dust particles and/or a surface to be cleaned. The unit (1) comprises a housing (30) having a housing wall (31) encompassing two internal sections (20, 22), and a movable surface (11) arranged at an interface of the two sections (20, 22), wherein a portion (32) of the housing wall (31) delimiting a first section (20) is provided with at least one opening (21), and wherein means for actuating the movable surface (11) are arranged in a second section (22). A portion (33) of the housing wall (31) delimiting the second section (22) is adapted to at least hinder exchange of air between an inside of this section (22) and an outside of the housing (30) at the location of this section (22), in order to at least hinder a migration of dust to the second section (22).

    摘要翻译： 真空清洁装置包括用于空气动力学影响灰尘颗粒和/或待清洁表面的单元（1）。 单元（1）包括具有包围两个内部部分（20,22）的壳体壁（31）和布置在两个部分（20,22）的界面处的可移动表面（11）的壳体（30），其中 限定第一部分（20）的壳体壁（31）的部分（32）设置有至少一个开口（21），并且其中用于致动可动表面（11）的装置布置在第二部分（22）中， 。 限定第二部分（22）的壳体壁（31）的部分（33）适于至少妨碍在该部分（22）的内部和壳体（30）的外部之间的空气交换， 该部分（22），以便至少阻止灰尘向第二部分（22）的迁移。

    Vacuum cleaning device, comprising a unit with a movable surface for generating an oscillating airflow
    7.
    发明授权
    Vacuum cleaning device, comprising a unit with a movable surface for generating an oscillating airflow 有权
    真空清洁装置，包括具有用于产生振荡气流的可移动表面的单元

    公开(公告)号：US08857013B2

    公开(公告)日：2014-10-14

    申请号：US13821258

    申请日：2011-09-21

    申请人： Gerben Kooijman ,  Jan Frederik Suijver ,  Yvonne Wendela Kruijt-Stegeman ,  Jeroen Herman Lammers

    发明人： Gerben Kooijman ,  Jan Frederik Suijver ,  Yvonne Wendela Kruijt-Stegeman ,  Jeroen Herman Lammers

    IPC分类号： A47L5/14 ,  A47L5/30 ,  B08B5/04 ,  A47L5/20 ,  A47L5/00 ,  A47L9/00

    CPC分类号： A47L5/20 ,  A47L5/00 ,  A47L5/14 ,  A47L5/30 ,  A47L9/0072 ,  A47L9/0081 ,  B08B5/04

    摘要： A vacuum cleaning device comprises a unit (1) in which an oscillating airflow is generated which substantially zero net flow and an asymmetry between the suction and the blowing phases, such that in the blowing phase a jet is generated. A generator (31) which is needed for generating the oscillating airflow comprises a movable surface (30) which is integrated in a wall (12) of a housing (10) having an internal space (11) and at least one opening (13) for allowing air to flow to and from the internal space (11). The jet can be generates when the so-called Strouhal number, being the frequency of the movement of the movable surface (30) multiplied by a characteristic dimension of the opening (13) and divided by the velocity of the air in the opening (13), is not higher than a predetermined maximum.

    摘要翻译： 真空清洁装置包括一个单元（1），其中产生基本上净流量的净流量和吸入和吹送相之间的不对称性的振荡气流，从而在吹塑阶段产生射流。 用于产生振荡气流所需的发生器（31）包括可移动表面（30），该可移动表面集成在具有内部空间（11）和至少一个开口（13）的壳体（10）的壁（12）中， 用于允许空气流入和流出内部空间（11）。 当所谓的Strouhal数，即可移动表面（30）的运动频率乘以开口（13）的特征尺寸并除以开口（13）中的空气的速度 ）不高于预定最大值。

    VACUUM CLEANING DEVICE
    8.
    发明申请
    VACUUM CLEANING DEVICE 有权
    真空清洁装置

    公开(公告)号：US20140047669A1

    公开(公告)日：2014-02-20

    申请号：US14008010

    申请日：2012-04-05

    申请人： Jan Frederik Suijver ,  Gerben Kooijman ,  Okke Ouweltjes ,  Jeroen Herman Lammers ,  Rene Henk Van Der Woude

    发明人： Jan Frederik Suijver ,  Gerben Kooijman ,  Okke Ouweltjes ,  Jeroen Herman Lammers ,  Rene Henk Van Der Woude

    IPC分类号： A47L9/04

    CPC分类号： A47L9/0483 ,  A47L9/0461

    摘要： A vacuum cleaning device comprises a unit (1) for aerodynamically affecting dust particles and/or a surface to be cleaned. The unit (1) comprises a housing (30) having a housing wall (31) encompassing two internal sections (20, 22), and a movable surface (11) arranged at an interface of the two sections (20, 22), wherein a portion (32) of the housing wall (31) delimiting a first section (20) is provided with at least one opening (21), and wherein means for actuating the movable surface (11) are arranged in a second section (22). A portion (33) of the housing wall (31) delimiting the second section (22) is adapted to at least hinder exchange of air between an inside of this section (22) and an outside of the housing (30) at the location of this section (22), in order to at least hinder a migration of dust to the second section (22).

    摘要翻译： 真空清洁装置包括用于空气动力学影响灰尘颗粒和/或待清洁表面的单元（1）。 单元（1）包括具有包围两个内部部分（20,22）的壳体壁（31）和布置在两个部分（20,22）的界面处的可移动表面（11）的壳体（30），其中 限定第一部分（20）的壳体壁（31）的部分（32）设置有至少一个开口（21），并且其中用于致动可动表面（11）的装置布置在第二部分（22）中， 。 限定第二部分（22）的壳体壁（31）的部分（33）适于至少妨碍在该部分（22）的内部和壳体（30）的外部之间的空气交换 该部分（22），以便至少阻止灰尘向第二部分（22）的迁移。

    Ultrasonic assembly with adjustable fluid lens
    9.
    发明授权
    Ultrasonic assembly with adjustable fluid lens 失效
    超声波组件带可调节液晶镜头

    公开(公告)号：US08475442B2

    公开(公告)日：2013-07-02

    申请号：US12663307

    申请日：2008-07-07

    申请人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

    发明人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

    IPC分类号： A61B18/04

    CPC分类号： A61N7/022 ,  A61B2017/00243 ,  A61N2007/0056 ,  G10K11/30

    摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the center of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.

    摘要翻译： 适于附接到导管的超声波组件，例如 用于治疗。 超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。 超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。 至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如， 当向电极施加电压时，界面的曲率。 在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。 在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。 这是例如 适用于人体组织的消融或凝血坏死治疗，例如 用于心房颤动治疗。 在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。

    Diagnostic systems and methods utilizing probe-ions exhibiting photon avalanche effect
    10.
    发明授权
    Diagnostic systems and methods utilizing probe-ions exhibiting photon avalanche effect 失效
    使用显示光子雪崩效应的探针离子的诊断系统和方法

    公开(公告)号：US08428695B2

    公开(公告)日：2013-04-23

    申请号：US12294961

    申请日：2007-03-19

    申请人： Jan Frederik Suijver

    发明人： Jan Frederik Suijver

    IPC分类号： A61B6/00 ,  A61B5/0476

    CPC分类号： A61K49/0067 ,  B82Y5/00

    摘要： The present disclosure provides advantageous systems and methods for significantly increasing the sensitivity and selectivity for diagnostic procedures, e.g., optical biopsy. The disclosed systems and methods use a highly non-linear effect, the so-called photon avalanche. In the regime close to the avalanche threshold, small differences in density of the probe-ion under investigation or the excitation power can result in very large changes in up-conversion emission intensity. Through this effect, it becomes possible to accurately measure the signal of an optical biopsy probe-ion only in the location(s) where its concentration is highest, while at the same time significantly reducing or eliminating measurement of background signal from probe-ions distributed with a somewhat lower concentration throughout the measurement volume. Also background auto-fluorescence of the surrounding healthy tissue is essentially absent with this technique.

    摘要翻译： 本公开提供了用于显着增加诊断程序（例如光学活检）的灵敏度和选择性的有利系统和方法。 所公开的系统和方法使用高度非线性的效应，即所谓的光子雪崩。 在接近雪崩阈值的状态下，正在研究的探针密度的小差异或激发功率可能导致上转换发射强度的非常大的变化。 通过这种效果，可以仅在其浓度最高的位置精确地测量光学活检探针的信号，同时显着地减少或消除来自探针离子分布的背景信号的测量 在整个测量体积中的浓度略低。 本技术基本上不存在周围健康组织的背景自动荧光。