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    Adjustable lens system for real-time applications
    3.
    发明授权
    Adjustable lens system for real-time applications 失效
    可调透镜系统，用于实时应用

    公开(公告)号：US08233221B2

    公开(公告)日：2012-07-31

    申请号：US12742658

    申请日：2008-12-10

    申请人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    发明人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    IPC分类号： G02B1/06 ,  G02B3/12

    CPC分类号： G02B3/14

    摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

    摘要翻译： 提供了一种可调节流体型透镜系统， 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器，例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用，例如， 在医疗领域内。 用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

    ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS
    7.
    发明申请
    ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS 失效
    可调镜头系统实时应用

    公开(公告)号：US20100259832A1

    公开(公告)日：2010-10-14

    申请号：US12742658

    申请日：2008-12-10

    申请人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    发明人： Jan Frederik Suijver ,  Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Stein Kuiper ,  Yan Shi

    IPC分类号： G02B3/14

    CPC分类号： G02B3/14

    摘要： An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for ‘on the fly’ high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.

    摘要翻译： 提供了一种可调节流体型透镜系统， 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器，例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压，控制电路被布置成改变电压，使得电压变化率被限制以避免界面的振荡，由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜，因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步（数字）电压，其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用，例如， 在医疗领域内。 用于“飞行”高速超声成像，或用于超声消融应用，其中可以在镜片调节期间遵循预定义的轨迹进行消融。

    Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids
    8.
    发明申请
    Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids 有权
    用于超声药物递送和相可转换液体治疗的方法和装置

    公开(公告)号：US20080200845A1

    公开(公告)日：2008-08-21

    申请号：US11914777

    申请日：2006-05-25

    申请人： Shunmugavelu Sokka ,  Christopher Stephen Hall ,  Marcel Rene Bohmer

    发明人： Shunmugavelu Sokka ,  Christopher Stephen Hall ,  Marcel Rene Bohmer

    IPC分类号： A61N7/02 ,  A61M37/00

    CPC分类号： A61M37/0092 ,  A61B8/12 ,  A61B8/546 ,  A61B2017/22008 ,  A61K41/0033 ,  A61K49/223 ,  A61N7/00 ,  A61N7/02

    摘要： An ultrasound treatment comprises applying ultrasound at a first energy level (32) to a region of interest (20) in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle (t1-t2). Ultrasound at a second energy level (34) is applied to the region of interest (20) during a second portion of the treatment cycle (t2-t3) for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.

    摘要翻译： 超声处理包括将第一能级（32）的超声波施用于受试者的感兴趣区域（20），以在治疗周期（t 1 -t 2）的第一部分期间激活空化成核剂。 在治疗周期（t 2 -t 3）的第二部分期间，在第二能量水平（34）处的超声被施加到感兴趣区域（20），以在存在激活的空化成核剂的情况下实现期望的热疗法 治疗周期的第一部分。 第二能级处于与第一能级不同的能级。

    Ultrasonic assembly with adjustable fluid lens
    9.
    发明授权
    Ultrasonic assembly with adjustable fluid lens 失效
    超声波组件带可调节液晶镜头

    公开(公告)号：US08475442B2

    公开(公告)日：2013-07-02

    申请号：US12663307

    申请日：2008-07-07

    申请人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

    发明人： Christopher Stephen Hall ,  Anna Teresa Fernandez ,  Jan Frederik Suijver

    IPC分类号： A61B18/04

    CPC分类号： A61N7/022 ,  A61B2017/00243 ,  A61N2007/0056 ,  G10K11/30

    摘要： An ultrasonic assembly suited for attachment to a catheter, e.g. for medical treatment. The ultrasonic assembly includes an adjustable ultrasonic focus mechanism arranged in connection with the ultrasonic transducer to adjust focus of ultrasonic waves generated by the transducer. The ultrasonic focus mechanism includes a fluid focus lens with at least two fluids separated by an interface such that ultrasonic waves are substantially reflected at the interface. At least two electrodes are arranged in connection with the fluid focus lens so as to allow adjustment of the interface shape, e.g. a curvature of the interface, when a voltage is applied to the electrodes. In preferred embodiments the electrodes are arranged so as to allow adjustment of the fluid focus lens in an elevation direction as well as in a radial direction. In simple embodiments with rotational symmetric geometry with the transducer positioned in the center of the fluid focus lens, ultrasonic waves can be focused in an annular ring. This is e.g. suitable for ablative or coagulative necrotic treatment of human tissue, e.g. for atrial fibrillation treatment. In some embodiments, the assembly has a number of separate individually adjustable fluid focus lens compartments allowing a more detailed control of the ultrasonic focus pattern.

    摘要翻译： 适于附接到导管的超声波组件，例如 用于治疗。 超声波组件包括与超声波换能器连接布置的可调超声波聚焦机构，以调节由换能器产生的超声波的焦点。 超声波聚焦机构包括流体聚焦透镜，其中至少两个流体被界面分开，使得超声波在界面处被大体上反射。 至少两个电极与流体聚焦透镜连接设置，以便允许调节界面形状，例如， 当向电极施加电压时，界面的曲率。 在优选实施例中，电极被布置成允许在高度方向以及径向方向上调整流体聚焦透镜。 在具有旋转对称几何形状的简单实施例中，换能器定位在流体聚焦透镜的中心，超声波可以聚焦在环形环中。 这是例如 适用于人体组织的消融或凝血坏死治疗，例如 用于心房颤动治疗。 在一些实施例中，组件具有多个单独可单独调节的流体聚焦透镜隔室，允许对超声波聚焦图案进行更详细的控制。