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1.
公开(公告)号:US06447775B1
公开(公告)日:2002-09-10
申请号:US09441063
申请日:1999-11-16
申请人: Dudley K. Strickland , Bradley T. Hyman , Maria Z. Kounnas , Robert D. Moir , Rudolph E. Tanzi , G. William Rebeck
发明人: Dudley K. Strickland , Bradley T. Hyman , Maria Z. Kounnas , Robert D. Moir , Rudolph E. Tanzi , G. William Rebeck
IPC分类号: A61K39395
CPC分类号: C07K14/705 , A61K38/00 , A61K2039/505 , C07K14/4711 , C07K14/775 , C07K16/28 , C07K2317/77 , G01N33/6896 , G01N2800/2821
摘要: The present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid &bgr;-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family.
摘要翻译: 本发明涉及用于通过阻断或干扰APP与低密度脂蛋白受体家族成员的缔合或结合来防止整合膜淀粉样蛋白β-前体蛋白(APP)的内吞和细胞内化的方法和组合物 。
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2.
公开(公告)号:US6156311A
公开(公告)日:2000-12-05
申请号:US687668
申请日:1996-07-26
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07K14/775 , C07K16/28 , G01N33/68 , A61K39/395
CPC分类号: C07K14/705 , C07K14/4711 , C07K14/775 , C07K16/28 , G01N33/6896 , A61K2039/505 , A61K38/00 , C07K2317/77 , G01N2800/2821
摘要: The present invention broadly relates to the treatment, diagnosis, and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for preventing the endocytosis and cellular internalization of integral membrane amyloid .beta.-precursor protein (APP) and its subsequent catabolism by blocking or interfering with the association or binding of APP with members of the low density lipoprotein receptor family.
摘要翻译: 本发明广泛涉及阿尔茨海默病的治疗,诊断和预防性预防。 更具体地,本发明涉及用于通过阻断或干扰APP与低密度成员的缔合或结合来防止整体膜淀粉样蛋白β-前体蛋白(APP)的内吞和细胞内化的方法和组合物 脂蛋白受体家族。
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