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    Alpha-2-macroglobulin diagnostic test
    3.
    发明授权
    Alpha-2-macroglobulin diagnostic test 失效
    α-2-巨球蛋白诊断试验

    公开(公告)号：US06342350B1

    公开(公告)日：2002-01-29

    申请号：US09148503

    申请日：1998-09-04

    申请人： Rudolph E. Tanzi ,  Bradley T. Hyman ,  George W. Rebeck ,  Deborah L. Blacker

    发明人： Rudolph E. Tanzi ,  Bradley T. Hyman ,  George W. Rebeck ,  Deborah L. Blacker

    IPC分类号： C12Q168

    CPC分类号： C07K14/8107 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N33/6896 ,  G01N2800/2821

    摘要： The disclosed invention relates to a diagnostic method for Alzheimer's disease based on genotyping the Alpha-2-Macroglobulin locus. A statistically significant correlation was found between inheritance of particular alleles of the Alpha-2-Macroglobulin gene and the occurrence of Alzheimer's disease. The diagnostic method involves the isolation of nucleic acid from an individual and subsequent genotyping by means such as sequencing or restriction fragment length polymorphism analysis. The invention also provides a means of genotype analysis through protein isotyping Alpha-2-Macroglobulin variant proteins. Finally, kits for nucleic acid analysis or protein analysis are taught.

    摘要翻译： 所公开的发明涉及基于α-2-巨球蛋白基因座的基因分型的阿尔茨海默病的诊断方法。 发现α-2-巨球蛋白基因特异性等位基因遗传与阿尔茨海默病发生之间有统计学意义的相关性。 诊断方法包括通过诸如测序或限制性片段长度多态性分析的方法从个体和随后的基因分型中分离核酸。 本发明还提供通过蛋白质同种型分析α-2-巨球蛋白变体蛋白的基因型分析方法。 最后，教导了用于核酸分析或蛋白质分析的试剂盒。

    In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease
    4.
    发明授权
    In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease 失效
    体内多光子诊断检测和神经变性疾病的成像

    公开(公告)号：US07668586B2

    公开(公告)日：2010-02-23

    申请号：US10001643

    申请日：2001-10-31

    申请人： Bradley T. Hyman ,  Richard Christie ,  Brian Bacskai ,  Watt W. Webb ,  Warren R. Zipfel

    发明人： Bradley T. Hyman ,  Richard Christie ,  Brian Bacskai ,  Watt W. Webb ,  Warren R. Zipfel

    IPC分类号： A61B6/00

    CPC分类号： G01N21/6486 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/1075 ,  A61B5/4064 ,  A61B5/4088 ,  A61K49/0021 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0056 ,  A61K49/0058 ,  G01N21/6456 ,  G01N21/6458

    摘要： The present invention is directed to a method of detecting a neurodegenerative disease in a mammal by activating brain tissue of the mammal by application of radiation under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to emit a fluorescence characteristic. The fluorescence characteristic is then compared to a standard fluorescence emitted by exciting healthy brain tissue of the mammal under the same conditions used to carry out the activating step. Brain tissue where the fluorescence characteristic differs from the standard fluorescence is identified as potentially having a neurodegenerative disease. Another aspect of the present invention is directed to a method of producing an image of brain tissue from a mammal by activating brain tissue of a mammal with radiation applied under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to produce fluorescence. The fluorescence is then collected to produce an image of the brain tissue.

    摘要翻译： 本发明涉及一种通过在有效促进脑组织的同时多光子激发并且发射荧光特性的条件下施加辐射来激活哺乳动物的脑组织来检测哺乳动物的神经变性疾病的方法。 然后将荧光特征与在用于进行活化步骤的相同条件下由哺乳动物激发的健康脑组织发射的标准荧光进行比较。 荧光特性与标准荧光差异的脑组织被鉴定为具有神经变性疾病。 本发明的另一方面涉及通过在有效促进脑组织的同时多光子激发并产生荧光的条件下施用辐射来激活哺乳动物的脑组织来产生来自哺乳动物的脑组织的图像的方法。 然后收集荧光以产生脑组织的图像。

    METHODS TO INHIBIT NEURODEGENERATION
    5.
    发明申请
    METHODS TO INHIBIT NEURODEGENERATION 审中-公开
    抑制神经元的方法

    公开(公告)号：US20130195866A1

    公开(公告)日：2013-08-01

    申请号：US13574006

    申请日：2011-01-19

    申请人： Brian J. Bacskai ,  Bradley T. Hyman ,  Kishore Kuchibhotla ,  Hai-Yan Wu

    发明人： Brian J. Bacskai ,  Bradley T. Hyman ,  Kishore Kuchibhotla ,  Hai-Yan Wu

    IPC分类号： A61K38/08

    CPC分类号： A61K38/08 ,  A61K38/1709

    摘要： Disclosed herein are methods, and compositions for inhibiting neurodegeneration, e.g., in neuronal cells. The methods and compositions the invention can be used to treat a neurodegenerative disorder, e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, and frontotemproal dementia. In some embodiments, the methods and compositions can be used to inhibit neurodegeneration, e.g., caused by tau-mediated synaptic neurodegeneration, encephalitis, brain trauma, or any disorder suffering from weakening synapses.

    摘要翻译： 本文公开了用于抑制神经变性的方法和组合物，例如在神经元细胞中。 本发明的方法和组合物可用于治疗神经变性疾病，例如阿尔茨海默氏病，帕金森病，亨廷顿氏病和额颞叶痴呆。 在一些实施方案中，所述方法和组合物可用于抑制神经变性，例如由tau介导的突触神经变性，脑炎，脑创伤或任何患有弱化突触的疾病引起的神经变性。