公开(公告)号：US20210000981A1

公开(公告)日：2021-01-07

申请号：US17007994

申请日：2020-08-31

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Hemraj Juwarker ,  Angelo Moreno ,  Nelson Chao ,  Eda Holl

IPC: A61K49/00 ,  A61K31/195 ,  A61K47/60 ,  A61P37/00 ,  A61P31/00 ,  A61P43/00 ,  A61K31/785

Abstract: Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the dendron comprising a focal point, a plurality of cationic termini, and a branched cationic polymer between the focal point and the plurality of cationic termini. Also disclosed polycationic polymers further comprising a detectable label; and a crosslinker, wherein the crosslinker links the detectable label and the focal point of the dendron. The resulting conjugated polycationic polymers may be used in tracking methods of methods of treating disease. Methods of using polycationic polymers to treat autoimmune diseases, infectious diseases and acute radiation syndrome are also disclosed.

公开(公告)号：US20180318454A1

公开(公告)日：2018-11-08

申请号：US15773765

申请日：2016-11-04

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Hemraj Juwarker ,  Angelo Moreno ,  Nelson Chao ,  Eda Holl

IPC: A61K49/00 ,  A61K31/785 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  A61K47/60

CPC classification number: A61K49/0054 ,  A61K31/195 ,  A61K31/785 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052 ,  A61K2123/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  G01N33/52

Abstract: Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the dendron comprising a focal point, a plurality of cationic termini, and a branched cationic polymer between the focal point and the plurality of cationic termini. Also disclosed polycationic polymers further comprising a detectable label; and a crosslinker, wherein the crosslinker links the detectable label and the focal point of the dendron. The resulting conjugated polycationic polymers may be used in tracking methods of methods of treating disease. Methods of using polycationic polymers to treat autoimmune diseases, infectious diseases and acute radiation syndrome are also disclosed.