公开(公告)号：US12158399B2

公开(公告)日：2024-12-03

申请号：US16323482

申请日：2017-08-07

Applicant: Duke University

Inventor： Luigi Racioppi ,  Erik Nelson ,  Wei Huang ,  Nelson Chao ,  Donald McDonnell

IPC: A61P35/00 ,  A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  G01N33/569 ,  G01N33/574

Abstract: Provided herein are compositions including a CaMKK2 inhibitor and an anti-cancer therapeutic agent and methods of treating cancer in a subject by administering a therapeutically effective amount of the composition to a subject. The subject may be selected for treatment based on an immune cell measurement of a sample from the subject. Methods of treating cancer by administering a therapeutically effective amount of a CaMKK2 inhibitor, and administering a therapeutically effective amount of an anti-cancer therapeutic agent to the subject are also provided. Kits including combination of a CaMKK2 inhibitor and another anti-cancer therapeutic agent are also provided.

公开(公告)号：US20210000981A1

公开(公告)日：2021-01-07

申请号：US17007994

申请日：2020-08-31

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Hemraj Juwarker ,  Angelo Moreno ,  Nelson Chao ,  Eda Holl

IPC: A61K49/00 ,  A61K31/195 ,  A61K47/60 ,  A61P37/00 ,  A61P31/00 ,  A61P43/00 ,  A61K31/785

Abstract: Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the dendron comprising a focal point, a plurality of cationic termini, and a branched cationic polymer between the focal point and the plurality of cationic termini. Also disclosed polycationic polymers further comprising a detectable label; and a crosslinker, wherein the crosslinker links the detectable label and the focal point of the dendron. The resulting conjugated polycationic polymers may be used in tracking methods of methods of treating disease. Methods of using polycationic polymers to treat autoimmune diseases, infectious diseases and acute radiation syndrome are also disclosed.

公开(公告)号：US10316365B2

公开(公告)日：2019-06-11

申请号：US14092291

申请日：2013-11-27

Applicant: DUKE UNIVERSITY

Inventor： John Chute ,  Joseph Nevins ,  Holly Dressman ,  Nelson Chao

IPC: C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6876

Abstract: The present invention relates, in general, to gene expression profiles, and in particular, to a peripheral blood gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.

公开(公告)号：US20180318454A1

公开(公告)日：2018-11-08

申请号：US15773765

申请日：2016-11-04

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Hemraj Juwarker ,  Angelo Moreno ,  Nelson Chao ,  Eda Holl

IPC: A61K49/00 ,  A61K31/785 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  A61K47/60

CPC classification number: A61K49/0054 ,  A61K31/195 ,  A61K31/785 ,  A61K47/60 ,  A61K49/0021 ,  A61K49/0052 ,  A61K2123/00 ,  A61P31/00 ,  A61P37/00 ,  A61P43/00 ,  G01N33/52

Abstract: Disclosed herein are polycationic polymers and methods of using the same. The polycationic polymer comprises a dendrimer or dendron, the dendrimer or the dendron comprising a focal point, a plurality of cationic termini, and a branched cationic polymer between the focal point and the plurality of cationic termini. Also disclosed polycationic polymers further comprising a detectable label; and a crosslinker, wherein the crosslinker links the detectable label and the focal point of the dendron. The resulting conjugated polycationic polymers may be used in tracking methods of methods of treating disease. Methods of using polycationic polymers to treat autoimmune diseases, infectious diseases and acute radiation syndrome are also disclosed.