公开(公告)号：US11713464B2

公开(公告)日：2023-08-01

申请号：US16645762

申请日：2018-09-10

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C12N15/115 ,  A61P35/00 ,  C12N2310/16

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.

公开(公告)号：US20240150772A1

公开(公告)日：2024-05-09

申请号：US18205390

申请日：2023-06-02

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00

CPC classification number: C12N15/115 ,  A61P35/00 ,  C12N2310/16

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.

公开(公告)号：US20200283773A1

公开(公告)日：2020-09-10

申请号：US16645762

申请日：2018-09-10

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.