公开(公告)号：US11713464B2

公开(公告)日：2023-08-01

申请号：US16645762

申请日：2018-09-10

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C12N15/115 ,  A61P35/00 ,  C12N2310/16

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.

公开(公告)号：US20200095636A1

公开(公告)日：2020-03-26

申请号：US16496871

申请日：2018-03-23

Applicant: Duke University

Inventor： Bruce Sullenger ,  Bethany Gray ,  Michael Nichols

IPC: C12Q1/6881 ,  C12N5/09 ,  C12N15/115

Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.

公开(公告)号：US20240150772A1

公开(公告)日：2024-05-09

申请号：US18205390

申请日：2023-06-02

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00

CPC classification number: C12N15/115 ,  A61P35/00 ,  C12N2310/16

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.

公开(公告)号：US20240141430A1

公开(公告)日：2024-05-02

申请号：US18128949

申请日：2023-03-30

Applicant: DUKE UNIVERSITY

Inventor： Bruce Sullenger ,  Bethany Gray ,  Michael Nichols

IPC: C12Q1/6881 ,  C12N5/09 ,  C12N15/115

CPC classification number: C12Q1/6881 ,  C12N5/0693 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/3517

Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.

公开(公告)号：US11634772B2

公开(公告)日：2023-04-25

申请号：US16496871

申请日：2018-03-23

Applicant: Duke University

Inventor： Bruce Sullenger ,  Bethany Gray ,  Michael Nichols

IPC: C12N15/115 ,  C12N5/09 ,  C12Q1/6881

Abstract: Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.

公开(公告)号：US20200283773A1

公开(公告)日：2020-09-10

申请号：US16645762

申请日：2018-09-10

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Michael Goldstein ,  Elizabeth D. Pratico ,  Michael Kastan ,  Bethany Gray

IPC: C12N15/115 ,  A61P35/00

Abstract: Provided herein are compositions including aptamers capable of binding to and/or inhibiting the activity of nucleolin. Methods of treating cancer in a subject by administering such compositions are also provided.